2-[(1R,2S,5R)-1-((S)-2-(R)-1,4-Dioxa-spiro[4.5]dec-2-yl-1-hydroxymethyl-ethoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

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Chemical Name:2-[(1R,2S,5R)-1-((S)-2-(R)-1,4-Dioxa-spiro[4.5]dec-2-yl-1-hydroxymethyl-ethoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone
CAS No.:122040-14-6
Molecular Formula:C₂₉H₄₄O₅
Molecular Weight:472.665
Hs Code.:

Synonyms:2-[(1R,2S,5R)-1-((S)-2-(R)-1,4-Dioxa-spiro[4.5]dec-2-yl-1-hydroxymethyl-ethoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

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Chemical Property of 2-[(1R,2S,5R)-1-((S)-2-(R)-1,4-Dioxa-spiro[4.5]dec-2-yl-1-hydroxymethyl-ethoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

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Technology Process of 2-[(1R,2S,5R)-1-((S)-2-(R)-1,4-Dioxa-spiro[4.5]dec-2-yl-1-hydroxymethyl-ethoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

There total 8 articles about 2-[(1R,2S,5R)-1-((S)-2-(R)-1,4-Dioxa-spiro[4.5]dec-2-yl-1-hydroxymethyl-ethoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 933-40-4
cycloxexanone dimethyl ketal

: 122040-13-5
2-[(1R,2S,5R)-1-((1S,3R)-3,4-Dihydroxy-1-hydroxymethyl-butoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

: 122040-14-6
2-[(1R,2S,5R)-1-((S)-2-(R)-1,4-Dioxa-spiro[4.5]dec-2-yl-1-hydroxymethyl-ethoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; Ambient temperature;
DOI:10.1016/0040-4039(88)85095-0

Reference yield:

: 58931-16-1
1-(benzyloxy)-4-penten-2-ol

: 122040-14-6
2-[(1R,2S,5R)-1-((S)-2-(R)-1,4-Dioxa-spiro[4.5]dec-2-yl-1-hydroxymethyl-ethoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

Guidance literature:: Multi-step reaction with 8 steps

1: MCPBA

3: TMSOTf

4: 86 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 6 h / 0 °C

5: H₂ / 10percent Pd/C

6: TMSOTf

7: 79 percent / titanium tetrachloride / CH₂Cl₂ / 1 h / -85 °C

8: 77 percent / PTS / CH₂Cl₂ / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; hydrogen; pyridinium p-toluenesulfonate; titanium tetrachloride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/0040-4039(88)85095-0

Reference yield:

: 1262957-82-3
1,5-bis(benzyloxy)pentane-2,4-diol

: 122040-14-6
2-[(1R,2S,5R)-1-((S)-2-(R)-1,4-Dioxa-spiro[4.5]dec-2-yl-1-hydroxymethyl-ethoxy)-2-isopropyl-5-methyl-cyclohexyl]-1-phenyl-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: TMSOTf

2: 86 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 6 h / 0 °C

3: H₂ / 10percent Pd/C

4: TMSOTf

5: 79 percent / titanium tetrachloride / CH₂Cl₂ / 1 h / -85 °C

6: 77 percent / PTS / CH₂Cl₂ / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; hydrogen; pyridinium p-toluenesulfonate; titanium tetrachloride; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/0040-4039(88)85095-0