diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl)azanediyl))diacetate

Base Information

• Chemical Name: diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl)azanediyl))diacetate
• CAS No.: 1421749-23-6
• Molecular Formula: C₂₇H₃₈N₂O₈
• Molecular Weight: 518.607
• Mol file: 1421749-23-6.mol

Synonyms:diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl)azanediyl))diacetate

Chemical Property of diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl)azanediyl))diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl)azanediyl))diacetate

There total 3 articles about diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl)azanediyl))diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,2'-[propane-1,3-diylbis(iminomethylene)]bis(6-methoxyphenol) (5767-55-5) + ethyl bromoacetate (105-36-2) → diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl)azanediyl))diacetate (1421749-23-6)

Guidance literature:

With potassium carbonate; In acetonitrile; for 24h; Inert atmosphere;

DOI:10.1016/j.saa.2012.11.100

Reference yield:

6,6'-{(1E,1'E)-[propane-1,3-diylbis(azanylylidene)]bis(methanylylidene)}bis(2-methoxyphenol) → diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl)azanediyl))diacetate (1421749-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 5 h / 20 °C

2: potassium carbonate / acetonitrile / 24 h / Inert atmosphere

With sodium tetrahydroborate; potassium carbonate; In methanol; acetonitrile;

DOI:10.1016/j.saa.2012.11.100

Reference yield:

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → diethyl-2,2'-(propane-1,3-diylbis((2-hydroxy-3-methoxybenzyl)azanediyl))diacetate (1421749-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1: chloroform / 5 h / 20 °C / Cooling

2: sodium tetrahydroborate / methanol / 5 h / 20 °C

3: potassium carbonate / acetonitrile / 24 h / Inert atmosphere

With sodium tetrahydroborate; potassium carbonate; In methanol; chloroform; acetonitrile;

DOI:10.1016/j.saa.2012.11.100

upstream raw materials:

2,2'-[propane-1,3-diylbis(iminomethylene)]bis(6-methoxyphenol)

ethyl bromoacetate

3-methoxy-2-hydroxybenzaldehyde