(R)-2-((2R,3R)-7-(3-(benzyloxy)phenyl)-3-((4-methoxybenzyl)oxy)heptan-2-yl)oxirane

Base Information

Chemical Name:(R)-2-((2R,3R)-7-(3-(benzyloxy)phenyl)-3-((4-methoxybenzyl)oxy)heptan-2-yl)oxirane
CAS No.:1380328-05-1
Molecular Formula:C₃₀H₃₆O₄
Molecular Weight:460.613
Hs Code.:

Synonyms:(R)-2-((2R,3R)-7-(3-(benzyloxy)phenyl)-3-((4-methoxybenzyl)oxy)heptan-2-yl)oxirane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((2R,3R)-7-(3-(benzyloxy)phenyl)-3-((4-methoxybenzyl)oxy)heptan-2-yl)oxirane

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Technology Process of (R)-2-((2R,3R)-7-(3-(benzyloxy)phenyl)-3-((4-methoxybenzyl)oxy)heptan-2-yl)oxirane

There total 13 articles about (R)-2-((2R,3R)-7-(3-(benzyloxy)phenyl)-3-((4-methoxybenzyl)oxy)heptan-2-yl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: (2R,3R)-7-(3-(benzyloxy)phenyl)-2-((R)-oxiran-2-yl)heptan-3-ol

: 824-94-2
p-methoxybenzyl chloride

: 1380328-05-1
(R)-2-((2R,3R)-7-(3-(benzyloxy)phenyl)-3-((4-methoxybenzyl)oxy)heptan-2-yl)oxirane

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 55h;
DOI:10.1021/jm300566h

Reference yield: 71.0%

: 1380328-04-0
C₂₄H₃₀O₅

: 824-94-2
p-methoxybenzyl chloride

: 1380328-05-1
(R)-2-((2R,3R)-7-(3-(benzyloxy)phenyl)-3-((4-methoxybenzyl)oxy)heptan-2-yl)oxirane

Guidance literature:: C₂₄H₃₀O₅; With sodium methylate; In methanol;

p-methoxybenzyl chloride; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1380328-03-9
(3S,4R)-8-(3-(benzyloxy)phenyl)-3-methyloct-1-en-4-ol

: 1380328-05-1
(R)-2-((2R,3R)-7-(3-(benzyloxy)phenyl)-3-((4-methoxybenzyl)oxy)heptan-2-yl)oxirane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 4 °C

1.2: 0.25 h / 20 °C

2.1: iodine(I) bromide / dichloromethane; toluene / 2 h / -78 °C

2.2: 0.75 h / 20 °C

3.1: methanol; sodium methylate / 2 h / 20 - 50 °C

4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 55 h / 20 °C

With methanol; sodium methylate; sodium hexamethyldisilazane; iodine(I) bromide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm300566h