(R)-7-(2-(((2R,4S,5R,6R)-6-(4-(3-(benzyloxy)phenyl)butyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methyl)-1,3-dithian-2-yl)-7-methyloct-1-en-4-ol

Base Information

Chemical Name:(R)-7-(2-(((2R,4S,5R,6R)-6-(4-(3-(benzyloxy)phenyl)butyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methyl)-1,3-dithian-2-yl)-7-methyloct-1-en-4-ol
CAS No.:1380328-08-4
Molecular Formula:C₄₃H₅₈O₅S₂
Molecular Weight:719.063
Hs Code.:

Synonyms:(R)-7-(2-(((2R,4S,5R,6R)-6-(4-(3-(benzyloxy)phenyl)butyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methyl)-1,3-dithian-2-yl)-7-methyloct-1-en-4-ol

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Chemical Property of (R)-7-(2-(((2R,4S,5R,6R)-6-(4-(3-(benzyloxy)phenyl)butyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methyl)-1,3-dithian-2-yl)-7-methyloct-1-en-4-ol

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Technology Process of (R)-7-(2-(((2R,4S,5R,6R)-6-(4-(3-(benzyloxy)phenyl)butyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methyl)-1,3-dithian-2-yl)-7-methyloct-1-en-4-ol

There total 21 articles about (R)-7-(2-(((2R,4S,5R,6R)-6-(4-(3-(benzyloxy)phenyl)butyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methyl)-1,3-dithian-2-yl)-7-methyloct-1-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: C₄₀H₅₂O₅S₂

: 24850-33-7
allyltributylstanane

: 1380328-08-4
(R)-7-(2-(((2R,4S,5R,6R)-6-(4-(3-(benzyloxy)phenyl)butyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methyl)-1,3-dithian-2-yl)-7-methyloct-1-en-4-ol

Guidance literature:: With (S)-[1,1']-binaphthalenyl-2,2'-diol; titanium(IV)isopropoxide; titanium tetrachloride; silver(l) oxide; In dichloromethane; at -15 ℃; for 63h;
DOI:10.1021/jm300566h

Reference yield:

: 289034-17-9
C₁₈H₂₀O₂

: 1380328-08-4
(R)-7-(2-(((2R,4S,5R,6R)-6-(4-(3-(benzyloxy)phenyl)butyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methyl)-1,3-dithian-2-yl)-7-methyloct-1-en-4-ol

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 0.25 h / -40 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

1.3: 2 h / -78 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 4 °C

2.2: 0.25 h / 20 °C

3.1: iodine(I) bromide / dichloromethane; toluene / 2 h / -78 °C

3.2: 0.75 h / 20 °C

4.1: methanol; sodium methylate / 2 h / 20 - 50 °C

5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 55 h / 20 °C

6.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / 20 °C / Inert atmosphere

6.2: 18 h / 4 °C / Inert atmosphere

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve

8.1: pyridinium p-toluenesulfonate / methanol; dichloromethane / 1.5 h / 20 °C

9.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.33 h / 20 °C / Molecular sieve

10.1: (S)-[1,1']-binaphthalenyl-2,2'-diol; titanium(IV)isopropoxide; titanium tetrachloride; silver(l) oxide / dichloromethane / 63 h / -15 °C

With methanol; n-butyllithium; tetrapropylammonium perruthennate; potassium tert-butylate; sodium methylate; (S)-[1,1']-binaphthalenyl-2,2'-diol; sodium hexamethyldisilazane; titanium(IV)isopropoxide; pyridinium p-toluenesulfonate; iodine(I) bromide; titanium tetrachloride; sodium hydride; 4-methylmorpholine N-oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm300566h

Reference yield:

: 1380328-03-9
(3S,4R)-8-(3-(benzyloxy)phenyl)-3-methyloct-1-en-4-ol

: 1380328-08-4
(R)-7-(2-(((2R,4S,5R,6R)-6-(4-(3-(benzyloxy)phenyl)butyl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl)methyl)-1,3-dithian-2-yl)-7-methyloct-1-en-4-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 4 °C

1.2: 0.25 h / 20 °C

2.1: iodine(I) bromide / dichloromethane; toluene / 2 h / -78 °C

2.2: 0.75 h / 20 °C

3.1: methanol; sodium methylate / 2 h / 20 - 50 °C

4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 55 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / 20 °C / Inert atmosphere

5.2: 18 h / 4 °C / Inert atmosphere

6.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve

7.1: pyridinium p-toluenesulfonate / methanol; dichloromethane / 1.5 h / 20 °C

8.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.33 h / 20 °C / Molecular sieve

9.1: (S)-[1,1']-binaphthalenyl-2,2'-diol; titanium(IV)isopropoxide; titanium tetrachloride; silver(l) oxide / dichloromethane / 63 h / -15 °C

With methanol; n-butyllithium; tetrapropylammonium perruthennate; sodium methylate; (S)-[1,1']-binaphthalenyl-2,2'-diol; sodium hexamethyldisilazane; titanium(IV)isopropoxide; pyridinium p-toluenesulfonate; iodine(I) bromide; titanium tetrachloride; sodium hydride; 4-methylmorpholine N-oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm300566h