(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester

Base Information

Chemical Name:(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester
CAS No.:868355-43-5
Molecular Formula:C₁₂H₁₃ClF₃NO₃
Molecular Weight:311.688
Hs Code.:

Synonyms:(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester

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Chemical Property of (R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester

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Technology Process of (R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester

There total 1 articles about (R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 868383-85-1
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid

: 64-17-5
ethanol

: 868355-43-5
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester

Guidance literature:: With hydrogenchloride;

Reference yield: 33.0%

: 291509-61-0
3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

: 868355-43-5
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester

: 7693-46-1
4-Nitrophenyl chloroformate

: 868383-86-2
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethyl-ester

Guidance literature:: 4-Nitrophenyl chloroformate; With dmap; In pyridine; at 20 ℃; for 1.5h;

(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester; In pyridine; at 20 ℃; for 2h;

3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one; In pyridine; at 20 ℃;

Reference yield: 31.0%

: 205059-12-7
1,3-dihydro-3-(4-piperidinyl)-imidazo[4,5-c]quinolin-2(2H)-one

: 868355-43-5
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester

: 7693-46-1
4-Nitrophenyl chloroformate

: 868355-42-4
4-(2-oxo-1,2-dihydro-imidazo[4,5-c]quinolin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-ethoxycarbonyl-ethylester

Guidance literature:: 4-Nitrophenyl chloroformate; With dmap; In pyridine; at 20 ℃; for 1h;

(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid ethylester; In pyridine; at 20 ℃; for 2h;

1,3-dihydro-3-(4-piperidinyl)-imidazo[4,5-c]quinolin-2(2H)-one; In pyridine; at 20 ℃; for 48h;