2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-2'-(tert-butylsulfamoylbiphenyl-4-yl)-3-phenyl-propionamide

Base Information

Chemical Name:2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-2'-(tert-butylsulfamoylbiphenyl-4-yl)-3-phenyl-propionamide
CAS No.:716316-99-3
Molecular Formula:C₃₈H₄₇BrN₂O₄SSi
Molecular Weight:735.858
Hs Code.:

Synonyms:2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-2'-(tert-butylsulfamoylbiphenyl-4-yl)-3-phenyl-propionamide

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Chemical Property of 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-2'-(tert-butylsulfamoylbiphenyl-4-yl)-3-phenyl-propionamide

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Technology Process of 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-2'-(tert-butylsulfamoylbiphenyl-4-yl)-3-phenyl-propionamide

There total 4 articles about 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-2'-(tert-butylsulfamoylbiphenyl-4-yl)-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 81136-07-4,42762-86-7
2-bromo-3-phenylpropionyl chloride

: 716317-12-3
4'-[2-(tert-butyldimethylsilyloxy)benzylamino]biphenyl-2-N-tert-butylsulfonamide

: 716316-99-3
2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-2'-(tert-butylsulfamoylbiphenyl-4-yl)-3-phenyl-propionamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.3987/com-04-10022

Reference yield:

: 89-95-2
2-methyl-benzyl alcohol

: 716316-99-3
2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-2'-(tert-butylsulfamoylbiphenyl-4-yl)-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 0.5 h / Heating

1.2: 63 percent / sodium borohydride / ethanol / 16 h / 20 °C

2.1: 88 percent / diisopropylethylamine / CH₂Cl₂ / 20 h / 20 °C

3.1: 68 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.3987/com-04-10022

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 716316-99-3
2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-2'-(tert-butylsulfamoylbiphenyl-4-yl)-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 0.5 h / Heating

1.2: 63 percent / sodium borohydride / ethanol / 16 h / 20 °C

2.1: 88 percent / diisopropylethylamine / CH₂Cl₂ / 20 h / 20 °C

3.1: 68 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.3987/com-04-10022