methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate

Base Information

Chemical Name:methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate
CAS No.:162584-13-6
Molecular Formula:C₂₀H₃₄O₅Si
Molecular Weight:382.572
Hs Code.:

Synonyms:methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate

Suppliers and Price of methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate

There total 5 articles about methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 3587-60-8
Benzyloxymethyl chloride

: 113494-90-9
methyl (2R,3S)-4-(tert-butyldimethylsilyloxy)-3-hydroxy-2-methylbutanoate

: 162584-13-6
methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 24h;
DOI:10.1039/c39870000992

Reference yield:

: 90414-36-1
methyl (3S)-3,4-dihydroxybutyrate

: 162584-13-6
methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / Et₃N, DMAP / CH₂Cl₂

2: 1.) LDA, 2.) TMEDA / 1.) THF, -50 deg C -> -10 deg C, 2.) -70 deg C, 4 h

3: 92 percent / i-Pr₂NEt, DMAP / CH₂Cl₂ / 60 h / Ambient temperature

With dmap; N,N,N,N,-tetramethylethylenediamine; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane;

Reference yield:

: 113494-89-6
methyl (S)-4-<(1,1-dimethylethyl)dimethylsiloxy>-3-hydroxybutanoate

: 162584-13-6
methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, 2.) TMEDA / 1.) THF, -50 deg C -> -10 deg C, 2.) -70 deg C, 4 h

2: 92 percent / i-Pr₂NEt, DMAP / CH₂Cl₂ / 60 h / Ambient temperature

With dmap; N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane;