(2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanol

Base Information

Chemical Name:(2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanol
CAS No.:162584-14-7
Molecular Formula:C₁₉H₃₄O₄Si
Molecular Weight:354.562
Hs Code.:

Synonyms:(2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanol

Chemical Property:

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Technology Process of (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanol

There total 4 articles about (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 162584-13-6
methyl (2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanoate

: 162584-14-7
(2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -25 ℃;

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 162584-14-7
(2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanol

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / i-Pr₂NEt, DMAP / CH₂Cl₂ / 60 h / Ambient temperature

2: 94 percent / DIBAL-H / tetrahydrofuran; hexane / -25 °C

With dmap; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 162584-14-7
(2R,3S)-3-benzyloxymethoxy-4-(tert-butyldimethylsilyloxy)-2-methylbutanol

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / Et₃N, DMAP / CH₂Cl₂

2: 1.) LDA, 2.) TMEDA / 1.) THF, -50 deg C -> -10 deg C, 2.) -70 deg C, 4 h

3: 92 percent / i-Pr₂NEt, DMAP / CH₂Cl₂ / 60 h / Ambient temperature

4: 94 percent / DIBAL-H / tetrahydrofuran; hexane / -25 °C

With dmap; N,N,N,N,-tetramethylethylenediamine; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;