Technology Process of (S,E)-(4-methylhexa-1,5-diene-1,4-diyl)dibenzene
There total 10 articles about (S,E)-(4-methylhexa-1,5-diene-1,4-diyl)dibenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
iodobenzene; (S)-(3-methylhexa-1,5-dien-3-yl)benzene;
With
sodium carbonate; triphenylphosphine;
In
N,N-dimethyl-formamide;
for 0.25h;
Inert atmosphere;
Molecular sieve;
With
palladium diacetate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/ja2039248
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / hexane / 0.5 h / 0 °C
1.2: Inert atmosphere; Reflux
2.1: diisobutylaluminium hydride / dichloromethane / 0 °C / Inert atmosphere
3.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere
4.1: tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; cesium fluoride / tetrahydrofuran; water / 36 h / 60 °C / Inert atmosphere
5.1: sodium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere; Molecular sieve
5.2: 16 h / 80 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); n-butyllithium; (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; tetra(n-butyl)ammonium hydrogensulfate; diisobutylaluminium hydride; sodium carbonate; triphenylphosphine; cesium fluoride; sodium hydroxide;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja2039248
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; cesium fluoride / tetrahydrofuran; water / 12 h / 60 °C / Inert atmosphere
2.1: sodium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere; Molecular sieve
2.2: 16 h / 80 °C / Inert atmosphere
With
tris-(dibenzylideneacetone)dipalladium(0); (R)-(+)-2,2′-bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl; sodium carbonate; triphenylphosphine; cesium fluoride;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/ja2039248
