(2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane

Base Information

Chemical Name:(2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane
CAS No.:272767-20-1
Molecular Formula:C₁₈H₂₆O₄
Molecular Weight:306.402
Hs Code.:

Synonyms:(2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane

Suppliers and Price of (2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane

There total 3 articles about (2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 213833-81-9
(2R,3R,5R,2'R,3a'S,6a'R)-2-(hexahydrofuro[2,3-b]furan-2'-yl)-5-isopropenyl-2,3-dimethylcyclohexanone

: 109-94-4
formic acid ethyl ester

: 272767-20-1
(2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane

Guidance literature:: With sodium hydride; In diethyl ether; at 20 ℃;
DOI:10.1016/S0040-4020(00)00110-1

Reference yield:

: 6485-40-1,2244-16-8
(R)-Carvone

: 272767-20-1
(2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuBr*Me₂S; TMSiCl

1.2: 35 percent / TrSbCl₆ / CH₂Cl₂ / -78 °C

2.1: 95 percent / NaH / diethyl ether / 20 °C

With chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; sodium hydride; In diethyl ether; 1.1: Methylation / 1.2: Mukaiyama reaction / 2.1: Formylation;
DOI:10.1016/S0040-4020(00)00110-1

Reference yield:

: 213833-82-0
(+/-)-2-methoxyhexahydrofuro[2,3-b]furan

: 272767-20-1
(2R,3R,5S)-2-[(2R,3aS,6aR)-hexahydrofuro[2,3-b]furan-2-yl]-6-hydroxymethylene-5-isopropenyl-2,3-dimethylcyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuBr*Me₂S; TMSiCl

1.2: 35 percent / TrSbCl₆ / CH₂Cl₂ / -78 °C

2.1: 95 percent / NaH / diethyl ether / 20 °C

With chloro-trimethyl-silane; copper(I) bromide dimethylsulfide complex; sodium hydride; In diethyl ether; 1.1: Methylation / 1.2: Mukaiyama reaction / 2.1: Formylation;
DOI:10.1016/S0040-4020(00)00110-1