[(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester
CAS No.:1262859-70-0
Molecular Formula:C₁₈H₂₃F₄N₃O₃
Molecular Weight:405.393
Hs Code.:

Synonyms:[(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

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Chemical Property of [(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

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Technology Process of [(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

There total 33 articles about [(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1262859-69-7
tert-butyl ((2R,5R)-5-(2-fluoro-5-nitrophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-yl)carbamate

: 1262859-70-0
[(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In 1,4-dioxane; at 45 ℃; for 3h; under 760.051 Torr; Inert atmosphere;
DOI:10.1021/acs.jmedchem.0c02143

Reference yield:

: 1262859-63-1
(R)-2-[(R)-2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3,3,3-trifluoro-2-methyl-propionic acid ethyl ester

: 1262859-70-0
[(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonia / methanol / 16 h / 50 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

3.1: potassium carbonate; N-Acetylcysteine / methanol / 16 h / 80 °C

4.1: hydrogen; sodium acetate / palladium 10% on activated carbon / methanol / 6 h / 50 °C

5.1: potassium nitrate; sulfuric acid / 2 h / 25 °C / Cooling with ice

5.2: Cooling

6.1: triethylamine / acetonitrile / 16 h / 25 °C

7.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol; tetrahydrofuran / 4 h / 50 °C

With N-Acetylcysteine; sulfuric acid; ammonia; hydrogen; sodium acetate; potassium carbonate; potassium nitrate; triethylamine; trifluoroacetic anhydride; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 1262859-65-3
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

: 1262859-70-0
[(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; N-Acetylcysteine / methanol / 16 h / 80 °C

2.1: hydrogen; sodium acetate / palladium 10% on activated carbon / methanol / 6 h / 50 °C

3.1: potassium nitrate; sulfuric acid / 2 h / 25 °C / Cooling with ice

3.2: Cooling

4.1: triethylamine / acetonitrile / 16 h / 25 °C

5.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol; tetrahydrofuran / 4 h / 50 °C

With N-Acetylcysteine; sulfuric acid; hydrogen; sodium acetate; potassium carbonate; potassium nitrate; triethylamine; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; methanol; isopropyl alcohol; acetonitrile;