6-(1-(2,6-difluorophenyl)-ethyl)-5-ethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Base Information

Chemical Name:6-(1-(2,6-difluorophenyl)-ethyl)-5-ethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
CAS No.:1005163-01-8
Molecular Formula:C₁₄H₁₄F₂N₂OS
Molecular Weight:296.341
Hs Code.:

Synonyms:6-(1-(2,6-difluorophenyl)-ethyl)-5-ethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

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Chemical Property of 6-(1-(2,6-difluorophenyl)-ethyl)-5-ethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Chemical Property:

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Technology Process of 6-(1-(2,6-difluorophenyl)-ethyl)-5-ethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

There total 5 articles about 6-(1-(2,6-difluorophenyl)-ethyl)-5-ethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 941295-43-8
4-(2,6-difluorophenyl)-2-ethyl-3-oxo-pentanoic acid ethyl ester

: 17356-08-0
thiourea

: 1005163-01-8
6-(1-(2,6-difluorophenyl)-ethyl)-5-ethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Guidance literature:: With sodium ethanolate; In ethanol; Heating;
DOI:10.1021/jm0708230

Reference yield:

: 359828-68-5
(2RS)-2-(2,6-difluorophenyl)propanoic acid

: 1005163-01-8
C₁₄H₁₄F₂N₂OS

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 0.25 h / 20 °C

2.1: triethylamine; magnesium chloride / acetonitrile / 2 h / 20 °C

2.2: 20 °C / Reflux

2.3: 0.25 h / 25 °C

3.1: sodium / ethanol / Reflux

With sodium; triethylamine; magnesium chloride; In ethanol; acetonitrile;
DOI:10.1021/jm500284x

Reference yield:

: 2-(2,6-difluorophenyl)propionic imidazolide

: 1005163-01-8
C₁₄H₁₄F₂N₂OS

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 2 h / 20 °C

1.2: 20 °C / Reflux

1.3: 0.25 h / 25 °C

2.1: sodium / ethanol / Reflux

With sodium; triethylamine; magnesium chloride; In ethanol; acetonitrile;
DOI:10.1021/jm500284x