359828-68-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(2,6-Difluoro-phenyl)-propionic acid is used as a building block for the synthesis of various pharmaceutical drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors. Its role as a selective inhibitor of cyclooxygenase-2 (COX-2) makes it a valuable component in the development of medications that target inflammation and pain.
Used in Medicinal Chemistry:
2-(2,6-Difluoro-phenyl)-propionic acid is utilized in the field of medicinal chemistry for its potential applications in the development of new organic compounds and pharmaceuticals. Its unique structure and properties contribute to the advancement of drug discovery and design.

Upstream product

• 680217-71-4 (2,6-difluorophenyl)acetic acid ethyl ester 
• 85068-28-6 2,6-difluorophenylacetic acid 
• 654-01-3 (2,6-difluorophenyl)acetonitrile 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 359828-74-3 ethyl 4-(2,6-difluorophenyl)-2,4-dimethyl-3-oxobutanoate 
• 255898-86-3 6-[1-(2,6-difluorophenyl)ethyl]-3,4-dihydro-5-methyl-2-thioxopyrimidin-4(3H)-one 
• 255898-86-3 6-(1-(2,6-difluorophenyl)ethyl)-5-methyl-3,4-dihydro-2-thioxopyrimidin-4(3H)-one 
• 359828-73-2 ethyl 4-(2,6-difluorophenyl)-3-oxopentanoate 

Relevant academic research and scientific papers

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.

Stereoselective synthesis of 2-substituted 6-[1-(2,6-difluorophenyl)ethyl]- 5-methylpyrimidin-4(3H)-ones

A procedure has been proposed for the synthesis of 2-(cyclopentylsulfanyl)- 6-[(1R)-1-(2,6-difluorophenyl) ethyl]-5-methylpyrimidin-4(3H)-one through intermediate (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (2R)-2-(2,6- difluorophenyl)propanoate which was