3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid

Base Information

• Chemical Name: 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid
• CAS No.: 362719-69-5
• Molecular Formula: C₃₀H₃₂F₈N₂O₇SSi
• Molecular Weight: 744.732
• Mol file: 362719-69-5.mol

Synonyms:3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid

Chemical Property of 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid

There total 5 articles about 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester (362719-67-3) → 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid (362719-69-5)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 4h;

DOI:10.1021/jm0204542

Reference yield:

1,1,1,3,3,3-hexafluoro-2-(1,3-thiazol-2-yl)propan-2-ol (362718-79-4) → 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid (362719-69-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 100 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

2.1: n-BuLi / diethyl ether; hexane / 1.5 h / -78 °C

2.2: 94 percent / diethyl ether; hexane / 2.5 h / -78 °C

3.1: pyridine; SOBr₂ / toluene / 1 h / 20 °C

4.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 2 h / 20 °C

4.2: 87.4 g / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 15 h / 20 °C

5.1: aq. LiOH / tetrahydrofuran; methanol / 4 h / 60 °C

With pyridine; lithium hydroxide; sulfurous dibromide; n-butyllithium; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane; toluene;

DOI:10.1021/jm0204542

Reference yield:

2-{1-trifluoromethyl-1-[(2-trimethylsilylethoxy)methoxy]-2,2,2-trifluoroethyl}thiazole (362718-80-7) → 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid (362719-69-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-BuLi / diethyl ether; hexane / 1.5 h / -78 °C

1.2: 94 percent / diethyl ether; hexane / 2.5 h / -78 °C

2.1: pyridine; SOBr₂ / toluene / 1 h / 20 °C

3.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 2 h / 20 °C

3.2: 87.4 g / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 15 h / 20 °C

4.1: aq. LiOH / tetrahydrofuran; methanol / 4 h / 60 °C

With pyridine; lithium hydroxide; sulfurous dibromide; n-butyllithium; potassium hexamethylsilazane; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; toluene;

DOI:10.1021/jm0204542

upstream raw materials:

3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester

1,1,1,3,3,3-hexafluoro-2-(1,3-thiazol-2-yl)propan-2-ol

2-{1-trifluoromethyl-1-[(2-trimethylsilylethoxy)methoxy]-2,2,2-trifluoroethyl}thiazole

5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole