3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester
• CAS No.: 362719-67-3
• Molecular Formula: C₃₂H₃₆F₈N₂O₇SSi
• Molecular Weight: 772.786
• Mol file: 362719-67-3.mol

Synonyms:3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester

Chemical Property of 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester

There total 4 articles about 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-ethoxy-2-oxoethyl)pyridin-1-ium-1-olate (3423-47-0) + 5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole (362719-65-1) → 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester (362719-67-3)

Guidance literature:

3-(2-ethoxy-2-oxoethyl)pyridin-1-ium-1-olate; With potassium hexamethylsilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene; at 20 ℃; for 2h;

5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; toluene; at 20 ℃; for 15h;

DOI:10.1021/jm0204542

Reference yield:

1,1,1,3,3,3-hexafluoro-2-(1,3-thiazol-2-yl)propan-2-ol (362718-79-4) → 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester (362719-67-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

2.1: n-BuLi / diethyl ether; hexane / 1.5 h / -78 °C

2.2: 94 percent / diethyl ether; hexane / 2.5 h / -78 °C

3.1: pyridine; SOBr₂ / toluene / 1 h / 20 °C

4.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 2 h / 20 °C

4.2: 87.4 g / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 15 h / 20 °C

With pyridine; sulfurous dibromide; n-butyllithium; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane; toluene;

DOI:10.1021/jm0204542

Reference yield:

2-{1-trifluoromethyl-1-[(2-trimethylsilylethoxy)methoxy]-2,2,2-trifluoroethyl}thiazole (362718-80-7) → 3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid ethyl ester (362719-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-BuLi / diethyl ether; hexane / 1.5 h / -78 °C

1.2: 94 percent / diethyl ether; hexane / 2.5 h / -78 °C

2.1: pyridine; SOBr₂ / toluene / 1 h / 20 °C

3.1: KHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 2 h / 20 °C

3.2: 87.4 g / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 15 h / 20 °C

With pyridine; sulfurous dibromide; n-butyllithium; potassium hexamethylsilazane; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; toluene;

DOI:10.1021/jm0204542

upstream raw materials:

3-(2-ethoxy-2-oxoethyl)pyridin-1-ium-1-olate

5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

1,1,1,3,3,3-hexafluoro-2-(1,3-thiazol-2-yl)propan-2-ol

2-{1-trifluoromethyl-1-[(2-trimethylsilylethoxy)methoxy]-2,2,2-trifluoroethyl}thiazole

Downstream raw materials:

3-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-2-(1-oxy-pyridin-3-yl)-3-{2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazol-5-yl}-propionic acid