5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Base Information

Chemical Name:5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole
CAS No.:362719-65-1
Molecular Formula:C₂₃H₂₆BrF₈NO₄SSi
Molecular Weight:672.506
Hs Code.:

5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Synonyms:5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Suppliers and Price of 5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

There total 3 articles about 5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 362719-63-9
(+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol

: 362719-65-1
5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Guidance literature:: With pyridine; sulfurous dibromide; In toluene; at 20 ℃; for 1h;
DOI:10.1021/jm0204542

Reference yield:

: 362718-79-4
1,1,1,3,3,3-hexafluoro-2-(1,3-thiazol-2-yl)propan-2-ol

: 362719-65-1
5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

2.1: n-BuLi / diethyl ether; hexane / 1.5 h / -78 °C

2.2: 94 percent / diethyl ether; hexane / 2.5 h / -78 °C

3.1: pyridine; SOBr₂ / toluene / 1 h / 20 °C

With pyridine; sulfurous dibromide; n-butyllithium; N-ethyl-N,N-diisopropylamine; In diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1021/jm0204542

Reference yield:

: 362718-80-7
2-{1-trifluoromethyl-1-[(2-trimethylsilylethoxy)methoxy]-2,2,2-trifluoroethyl}thiazole

: 362719-65-1
5-[bromo-(3-cyclopropoxy-4-difluoromethoxy-phenyl)-methyl]-2-[2,2,2-trifluoro-1-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-ethyl]-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; hexane / 1.5 h / -78 °C

1.2: 94 percent / diethyl ether; hexane / 2.5 h / -78 °C

2.1: pyridine; SOBr₂ / toluene / 1 h / 20 °C

With pyridine; sulfurous dibromide; n-butyllithium; In diethyl ether; hexane; toluene;
DOI:10.1021/jm0204542