N-[4-(4-Amino-piperazine-1-carbonyl)-2-chloro-5-methoxy-phenyl]-2-(4-chloro-phenoxy)-acetamide

Base Information

Chemical Name:N-[4-(4-Amino-piperazine-1-carbonyl)-2-chloro-5-methoxy-phenyl]-2-(4-chloro-phenoxy)-acetamide
CAS No.:85630-76-8
Molecular Formula:C₂₀H₂₂Cl₂N₄O₄
Molecular Weight:453.325
Hs Code.:

Synonyms:N-[4-(4-Amino-piperazine-1-carbonyl)-2-chloro-5-methoxy-phenyl]-2-(4-chloro-phenoxy)-acetamide

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Chemical Property of N-[4-(4-Amino-piperazine-1-carbonyl)-2-chloro-5-methoxy-phenyl]-2-(4-chloro-phenoxy)-acetamide

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Technology Process of N-[4-(4-Amino-piperazine-1-carbonyl)-2-chloro-5-methoxy-phenyl]-2-(4-chloro-phenoxy)-acetamide

There total 3 articles about N-[4-(4-Amino-piperazine-1-carbonyl)-2-chloro-5-methoxy-phenyl]-2-(4-chloro-phenoxy)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.8%

: 30651-60-6
piperazin-1-yl-amine

: 85630-49-5
4-{[(p-chlorophenoxy)acetyl]amino}-5-chloro-2-methoxybenzoic acid

: 85630-76-8
N-[4-(4-Amino-piperazine-1-carbonyl)-2-chloro-5-methoxy-phenyl]-2-(4-chloro-phenoxy)-acetamide

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; In dichloromethane; for 1h;
DOI:10.1021/jm00361a022

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 85630-76-8
N-[4-(4-Amino-piperazine-1-carbonyl)-2-chloro-5-methoxy-phenyl]-2-(4-chloro-phenoxy)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / pyridine / benzene / 5 h / Heating

2: 35.8 percent / triethylamine, ethyl chloroformate / CH₂Cl₂ / 1 h

With pyridine; chloroformic acid ethyl ester; triethylamine; In dichloromethane; benzene;
DOI:10.1021/jm00361a022

Reference yield:

: 4122-68-3
4-chlorophenyloxyacetyl chloride

: 85630-76-8
N-[4-(4-Amino-piperazine-1-carbonyl)-2-chloro-5-methoxy-phenyl]-2-(4-chloro-phenoxy)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / pyridine / benzene / 5 h / Heating

2: 35.8 percent / triethylamine, ethyl chloroformate / CH₂Cl₂ / 1 h

With pyridine; chloroformic acid ethyl ester; triethylamine; In dichloromethane; benzene;
DOI:10.1021/jm00361a022