8-[4-fluoro-2-(trifluoromethyl)phenyl]-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Base Information

Chemical Name:8-[4-fluoro-2-(trifluoromethyl)phenyl]-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
CAS No.:1314786-19-0
Molecular Formula:C₂₄H₁₈F₄N₆O
Molecular Weight:482.44
Hs Code.:

Synonyms:8-[4-fluoro-2-(trifluoromethyl)phenyl]-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

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Chemical Property of 8-[4-fluoro-2-(trifluoromethyl)phenyl]-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

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Technology Process of 8-[4-fluoro-2-(trifluoromethyl)phenyl]-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

There total 4 articles about 8-[4-fluoro-2-(trifluoromethyl)phenyl]-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 870838-56-5
1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole

: 1314787-74-0
C₁₃H₈F₄N₄

: 1314786-19-0
8-[4-fluoro-2-(trifluoromethyl)phenyl]-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tert-butyl alcohol; at 110 ℃; for 20h; Inert atmosphere;

Reference yield:

: 454-16-0
1-fluoro-2-methoxy-4-nitrobenzene

: 1314786-19-0
8-[4-fluoro-2-(trifluoromethyl)phenyl]-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 16 h / 125 °C / Autoclave; Inert atmosphere

2.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 3 h / 50 °C

3.1: sodium nitrite; sulfuric acid / acetic acid / 0.5 h / 10 - 20 °C

3.2: 1 h / 20 °C

3.3: Alkaline conditions

4.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With thiophene; sulfuric acid; hydrogen; potassium carbonate; caesium carbonate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In methanol; acetic acid; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 958245-17-5
1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole

: 1314786-19-0
8-[4-fluoro-2-(trifluoromethyl)phenyl]-N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 3 h / 50 °C

2.1: sodium nitrite; sulfuric acid / acetic acid / 0.5 h / 10 - 20 °C

2.2: 1 h / 20 °C

2.3: Alkaline conditions

3.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With thiophene; sulfuric acid; hydrogen; caesium carbonate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; XPhos; In methanol; acetic acid; tert-butyl alcohol;