2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran

Base Information

• Chemical Name: 2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran
• CAS No.: 117822-65-8
• Molecular Formula: C₁₈H₁₉FN₂O₂S
• Molecular Weight: 346.425

Synonyms:2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran

Chemical Property of 2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran

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Technology Process of 2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran

There total 2 articles about 2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-cyano-3-(4-fluorophenyl)prop-2-enethioamide (97579-25-4) + dimedone (126-81-8) → 2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran (117822-65-8)

Guidance literature:

With triethylamine; In benzene; for 0.0833333h; Heating;

Reference yield: 43.0%

thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid (104309-80-0) → 2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran (117822-65-8)

Guidance literature:

With triethylamine; In benzene; for 0.5h; Heating;

Reference yield: 45.0%

2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran (117822-65-8) → 2-amino-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (107752-99-8)

Guidance literature:

With triethylamine; malononitrile; In benzene; for 1.5h; Heating;

upstream raw materials:

thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid

2-cyano-3-(4-fluorophenyl)prop-2-enethioamide

dimedone

Downstream raw materials:

2-amino-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile

7,7-dimethyl-5-oxo-4-(4-fluorophenyl)-3-cyano-3,4,5,6,7,8-hexahydro-2(1H)-quinolinethione

3-amino-2-benzoyl-7,7-dimethyl-5-oxo-4-(4-fluorophenyl)-4,5,6,7,8,9-hexahydrothieno<2,3-b>quinoline

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