(4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid benzhydryl-amide

Base Information

Chemical Name:(4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid benzhydryl-amide
CAS No.:1053709-03-7
Molecular Formula:C₃₁H₄₂N₂O₂Si
Molecular Weight:502.772
Hs Code.:

Synonyms:(4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid benzhydryl-amide

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Chemical Property of (4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid benzhydryl-amide

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Technology Process of (4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid benzhydryl-amide

There total 4 articles about (4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid benzhydryl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160140-77-2
5-((tert-butyloxycarbonyl)amino)-4-((tert-butyldimethylsilyl)oxy)-6-phenylhexanoic acid benzhydrylamide

: 1053709-03-7
(4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid benzhydryl-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jm00041a005

Reference yield:

: 133333-27-4
tert-butyl (1S)-1-[(2S)-5-oxotetrahydrofuran-2-yl]-2-phenylethylcarbamate

: 1053709-03-7
(4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid benzhydryl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / 2N LiOH / tetrahydrofuran / 2 h / Ambient temperature

2: 88 percent / imidazole / dimethylformamide / 8 h / 55 °C

3: 57 percent / DCC / CH₂Cl₂ / 3 h / Ambient temperature

4: TFA / CH₂Cl₂ / 3 h / Ambient temperature

With 1H-imidazole; lithium hydroxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00041a005

Reference yield:

: 153353-99-2
(4S,5S)-5-tert-Butoxycarbonylamino-4-hydroxy-6-phenyl-hexanoic acid

: 1053709-03-7
(4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoic acid benzhydryl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / imidazole / dimethylformamide / 8 h / 55 °C

2: 57 percent / DCC / CH₂Cl₂ / 3 h / Ambient temperature

3: TFA / CH₂Cl₂ / 3 h / Ambient temperature

With 1H-imidazole; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00041a005