5-((tert-butyloxycarbonyl)amino)-4-((tert-butyldimethylsilyl)oxy)-6-phenylhexanoic acid

Base Information

Chemical Name:5-((tert-butyloxycarbonyl)amino)-4-((tert-butyldimethylsilyl)oxy)-6-phenylhexanoic acid
CAS No.:128211-42-7
Molecular Formula:C₂₃H₃₉NO₅Si
Molecular Weight:437.652
Hs Code.:

Synonyms:5-((tert-butyloxycarbonyl)amino)-4-((tert-butyldimethylsilyl)oxy)-6-phenylhexanoic acid

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Chemical Property of 5-((tert-butyloxycarbonyl)amino)-4-((tert-butyldimethylsilyl)oxy)-6-phenylhexanoic acid

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Technology Process of 5-((tert-butyloxycarbonyl)amino)-4-((tert-butyldimethylsilyl)oxy)-6-phenylhexanoic acid

There total 2 articles about 5-((tert-butyloxycarbonyl)amino)-4-((tert-butyldimethylsilyl)oxy)-6-phenylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 153353-99-2
(4S,5S)-5-tert-Butoxycarbonylamino-4-hydroxy-6-phenyl-hexanoic acid

: 128211-42-7
5-((tert-butyloxycarbonyl)amino)-4-((tert-butyldimethylsilyl)oxy)-6-phenylhexanoic acid

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 55 ℃; for 8h;
DOI:10.1021/jm00041a005

Reference yield:

: 133333-27-4
tert-butyl (1S)-1-[(2S)-5-oxotetrahydrofuran-2-yl]-2-phenylethylcarbamate

: 128211-42-7
5-((tert-butyloxycarbonyl)amino)-4-((tert-butyldimethylsilyl)oxy)-6-phenylhexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / 2N LiOH / tetrahydrofuran / 2 h / Ambient temperature

2: 88 percent / imidazole / dimethylformamide / 8 h / 55 °C

With 1H-imidazole; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00041a005