(S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate

Base Information

Chemical Name:(S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate
CAS No.:1100155-37-0
Molecular Formula:C₂₄H₃₁F₂NO₃
Molecular Weight:419.512
Hs Code.:

Synonyms:(S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate

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Chemical Property of (S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate

Chemical Property:

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Technology Process of (S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate

There total 6 articles about (S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261951-68-2
4-fluoro-3-methylbenzylamine

: 1100155-35-8
methyl (S)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-6-oxohexanoate

: 1100155-37-0
(S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 8h;

Reference yield:

: 1100155-27-8
(S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid

: 1100155-37-0
(S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 3 h / 0 - 25 °C

2: sulfuric acid / 8 h / 25 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C

4: Dess-Martin periodane / dichloromethane / 3 h / 25 °C

5: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 25 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: C₂₂H₂₅FO₄

: 1100155-37-0
(S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 8 h / 25 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C

3: Dess-Martin periodane / dichloromethane / 3 h / 25 °C

4: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 25 °C

With sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; In ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.02.010