(S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid

Base Information

Chemical Name:(S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid
CAS No.:1100155-27-8
Molecular Formula:C₂₁H₂₃FO₄
Molecular Weight:358.41
Hs Code.:

Synonyms:(S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid

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Chemical Property of (S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid

Chemical Property:

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Technology Process of (S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid

There total 3 articles about (S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1100155-25-6
(3S,5R)-3-(4-(benzyloxy)but-2-enyl)-5-(4-fluorophenyl)dihydrofuran-2(3H)-one

: 1100155-27-8
(S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid

Guidance literature:: (3S,5R)-3-(4-(benzyloxy)but-2-enyl)-5-(4-fluorophenyl)dihydrofuran-2(3H)-one; With water; potassium hydroxide; In 1,4-dioxane; at 20 - 25 ℃;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 69152-88-1,81028-03-7,80885-30-9
4-(benzyloxy)-2-buten-1-ol

: 1100155-27-8
(S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 - 25 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -70 - 25 °C

3: potassium hydroxide / 1,4-dioxane; water / 0.5 h / 25 °C

With 1H-imidazole; iodine; triphenylphosphine; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: 113729-13-8
(2EZ)-4-benzyloxy-1-iodo-2-butene

: 1100155-27-8
(S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -70 - 25 °C

2: potassium hydroxide / 1,4-dioxane; water / 0.5 h / 25 °C

With potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/j.bmcl.2011.02.010