(S)-6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide

Base Information

Chemical Name:(S)-6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide
CAS No.:1100155-39-2
Molecular Formula:C₂₃H₃₀F₂N₂O₃
Molecular Weight:420.5
Hs Code.:

Synonyms:(S)-6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide

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Chemical Property of (S)-6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide

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Technology Process of (S)-6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide

There total 7 articles about (S)-6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1100155-37-0
(S)-methyl 6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hexanoate

: 1100155-39-2
(S)-6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide

Guidance literature:: With potassium cyanide; hydroxylamine; In tetrahydrofuran; methanol; water; at 20 ℃; for 72h;

Reference yield:

: 1100155-27-8
(S)-6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-hydroxyethyl)hex-4-enoic acid

: 1100155-39-2
(S)-6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran / 3 h / 0 - 25 °C

2: sulfuric acid / 8 h / 25 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C

4: Dess-Martin periodane / dichloromethane / 3 h / 25 °C

5: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 25 °C

6: potassium cyanide; hydroxylamine / tetrahydrofuran; methanol; water / 72 h / 25 °C

With potassium cyanide; sulfuric acid; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium tris(acetoxy)borohydride; sodium hydride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: 1100155-31-4
(S)-methyl 6-(benzyloxy)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)hex-4-enoate

: 1100155-39-2
(S)-6-(4-fluoro-3-methylbenzylamino)-2-((R)-2-(4-fluorophenyl)-2-methoxyethyl)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C

2: Dess-Martin periodane / dichloromethane / 3 h / 25 °C

3: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 8 h / 25 °C

4: potassium cyanide; hydroxylamine / tetrahydrofuran; methanol; water / 72 h / 25 °C

With potassium cyanide; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2011.02.010