2-Acetyl-5-[3-(trifluoromethyl)phenyl]thiophene

Base Information

Chemical Name:2-Acetyl-5-[3-(trifluoromethyl)phenyl]thiophene
CAS No.:893735-18-7
Molecular Formula:C₁₃H₉F₃OS
Molecular Weight:270.275
Hs Code.:
DSSTox Substance ID:DTXSID101224507
Nikkaji Number:J2.643.210C

Synonyms:893735-18-7;2-Acetyl-5-[3-(trifluoromethyl)phenyl]thiophene;1-{5-[3-(Trifluoromethyl)phenyl]-2-thienyl}ethanon;1-[5-[3-(trifluoromethyl)phenyl]thiophen-2-yl]ethanone;1-[5-[3-(Trifluoromethyl)phenyl]-2-thienyl]ethanone;1-{5-[3-(trifluoromethyl)phenyl]-2-thienyl}ethanone;1-(5-(3-(Trifluoromethyl)phenyl)thiophen-2-yl)ethanone;SCHEMBL216900;DTXSID101224507;AKOS000124010;BB 0223051;A1-35618;1-(5-(3-(Trifluoromethyl)phenyl)thien-2-yl)ethanone

Suppliers and Price of 2-Acetyl-5-[3-(trifluoromethyl)phenyl]thiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Acetyl-5-[3-(trifluoromethyl)phenyl]thiophene

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:270.03262057
Heavy Atom Count:18
Complexity:316

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=CC=C(S1)C2=CC(=CC=C2)C(F)(F)F

Technology Process of 2-Acetyl-5-[3-(trifluoromethyl)phenyl]thiophene

There total 4 articles about 2-Acetyl-5-[3-(trifluoromethyl)phenyl]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 30955-94-3
2-acetyl-5-iodothiophene

: 401-81-0
m-trifluoromethylphenyl iodide

: 893735-18-7
1-(5-(3-(trifluoromethyl)phenyl)thiophene-2-yl)ethanone

Guidance literature:: 2-acetyl-5-iodothiophene; With indium; hepatdecane; lithium chloride; In tetrahydrofuran; at 30 ℃; for 0.333333h;

m-trifluoromethylphenyl iodide; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 40 ℃; for 4h; Inert atmosphere;
DOI:10.1002/anie.200802292

Reference yield: 55.0%

: 88-15-3,97511-16-5
2-Acetylthiophene

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 893735-18-7
1-(5-(3-(trifluoromethyl)phenyl)thiophene-2-yl)ethanone

Guidance literature:: With PdCl(C₃H₅)(bis(diphenylphosphino)butane); potassium acetate; In N,N-dimethyl acetamide; at 150 ℃; for 24h; Schlenk technique; Inert atmosphere;
DOI:10.1002/ejic.201500227

Reference yield: 48.0%

: 5370-25-2
2-Acetyl-5-bromothiophene

: 402-26-6
3-(trifluoromethyl)phenylmagnesium bromide

: 18494-73-0
5,5'-di(1-oxoethyl)-2,2'-bithiophene

: 893735-18-7
1-(5-(3-(trifluoromethyl)phenyl)thiophene-2-yl)ethanone

: 580-82-5
3,3'-bis(trifluoromethyl)biphenyl

Guidance literature:: 3-(trifluoromethyl)phenylmagnesium bromide; With bismuth(III) chloride;

2-Acetyl-5-bromothiophene; With potassium phosphate; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0030-1260554