30955-94-3

Usage

Uses

Used in Chemical Synthesis:
2-ACETYL-5-IODOTHIOPHENE is used as a chemical intermediate for the synthesis of other complex organic compounds. Its unique structure allows it to participate in various chemical reactions, leading to the formation of new molecules with different properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-ACETYL-5-IODOTHIOPHENE is used as a building block for the development of novel therapeutic agents. Its reactivity enables the creation of new drug candidates with potential applications in treating various diseases and medical conditions.
Used in Material Science:
2-ACETYL-5-IODOTHIOPHENE can be utilized in the development of new materials with specific properties, such as conductivity, magnetism, or optical characteristics. These materials can find applications in various fields, including electronics, sensors, and energy storage devices.
Used in Research and Development:
As a versatile compound, 2-ACETYL-5-IODOTHIOPHENE is also used in research and development laboratories for studying its chemical properties, reactivity, and potential applications in different fields. This helps scientists and researchers to better understand its behavior and develop new strategies for its utilization.
For example, it can react with 5-Ethyl-4-methyl-thiazole to get 2-Acetyl-5-(5-ethyl-4-methyl-2-thiazolyl)thiophene in the presence of solvent acetonitrile and other conditions of heating for 4 hours. This reaction demonstrates the compound's ability to form new molecules with potential applications in various industries.

InChI:InChI=1/C6H5IOS/c1-4(8)5-2-3-6(7)9-5/h2-3H,1H3

Upstream product

• 625-88-7 2,5-diiodothiophene 
• 75-36-5 acetyl chloride 
• 857360-63-5 5-iodo-[2]thienylmercury ⁽¹⁺⁾; chloride 
• 88-15-3 2-Acetylthiophene 
• 6310-09-4 2-acetyl-5-chlorothiophene 
• 3437-95-4 2-Iodothiophene 
• 108-24-7 acetic anhydride 

Downstream Products

• 128608-12-8 (Z)-2-acetyl-5-(β-phenylvinyl)thiophene 
• 125972-78-3 trans-2-acetyl-5-(β-phenylvinyl)thiophene 
• 88653-55-8 5-acetylthiophene-2-carbonitrile 
• 1665-41-4 5-phenyl-2-acetylthiophene 
• 893735-18-7 1-(5-(3-(trifluoromethyl)phenyl)thiophene-2-yl)ethanone 
• 948841-08-5 (E)-1-(5-iodothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one 
• 18494-73-0 5,5'-di(1-oxoethyl)-2,2'-bithiophene 
• 6161-50-8 3,3'-dimethoxybiphenyl 
• 893735-15-4 1-[5-(3-methoxyphenyl)thiophene-2-yl]ethanone 
• 51335-90-1 1-[5-(4-chlorophenyl)thiophen-2-yl]ethan-1-one 
• 2050-68-2 4,4'-dichlorobiphenyl 
• 92-52-4 biphenyl 
• 13918-67-7 1-(5-(4-methoxyphenyl)thiophen-2-yl)ethan-1-one 
• 2132-80-1 4,4'-Dimethoxybiphenyl 

Relevant academic research and scientific papers

Cobalt-catalyzed preparation of arylindium reagents from aryl and heteroaryl bromides

A cobalt-bathophenanthroline catalyst has been developed for the direct preparation of a variety of arylindium reagents from the corresponding aryl and heteroaryl bromides in the presence of indium metal and lithium chloride. The thus-formed arylindium reagents undergo efficient palladium-catalyzed cross-coupling reactions with aryl iodides, tolerating various functional groups including hydroxy and free amino groups.

METHOD OF PRODUCING IODIZING AGENT, AND METHOD OF PRODUCING AROMATIC IODINE COMPOUND

A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved.

Bis-(trifluoroacetoxy)iodobenzene-iodine system: An efficient and selective reagent for iodination of thiophene derivatives

Bis-(trifluoroacetoxy)iodobenzene-iodine system is a good iodinating reagent of thiophene derivatives giving products with iodine atom in α-position on the thiophene ring.

Reevaluation of benzyltrimethylammonium dichloroiodide, previously reported to be a selective iodinating agent

Benzyltrimethylammonium dichloroiodate, previously reported as an iodinating agent of thiophenes, appears to be a selective chlorinating agent of both thienyl and furyl derivatives containing a carbonyl group.

Photochemical Synthesis of Phenyl-2-thienyl Derivatives

The irradiation (in benzene solution) of 5-bromo- and 5-iodo-thiophene-2-carbaldehyde or the corresponding methyl ketones furnishes the corresponding 5-phenyl derivatives.The same reactivity for other halogenothiophenes is reported: 3,5-dibromothiophene-2-carbaldehyde furnishes the 3-bromo-5-phenyl-2-thienyl derivative while the corresponding di-iodo compound yields 3,5-diphenylthiophene-2-carbaldehyde.In contrast, 5-acetyl-2,3-di-iodothiophene furnishes only the photosubstitution pruduct at C-5.Generally the iodine-containing compounds are more reactive and more stable under the reaction conditions than ones bearing bromine, in agreement with previous reports on the corresponding furan photochemistry.

Kinetics of the Detritiation of a Series of 4- and 5-Substituted 2-(acetyl)thiophenes

A series of 4- and 5-substituted 2-(acetyl)thiophenes have been prepared and the kinetics of the hydroxide-catalysed detritiation studied at 25.0 deg C.The second-order detritiation rate constants parallel those observed for the corresponding meta- and para-substituted acetophenones but as the reaction constant ρ is higher (1.61) the range of reactivity is much wider than that witnessed for the acetophenones.