[4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrol-3-yl]methanol

Base Information

Chemical Name:[4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrol-3-yl]methanol
CAS No.:1445890-99-2
Molecular Formula:C₁₇H₁₄ClFN₂O
Molecular Weight:316.762
Hs Code.:

Synonyms:[4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrol-3-yl]methanol

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Chemical Property of [4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrol-3-yl]methanol

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Technology Process of [4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrol-3-yl]methanol

There total 4 articles about [4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrol-3-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445890-97-0
ethyl 4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrole-3-carboxylate

: 1445890-99-2
[4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrol-3-yl]methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1188163-01-0
ethyl 4-(2-chlorophenyl)-1H-pyrrole-3-carboxylate

: 1445890-99-2
[4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrol-3-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; diethyl ether;

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 1445890-99-2
[4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrol-3-yl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride; ammonium chloride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

1.2: 1 h / 20 °C

2.1: sodium t-butanolate / tetrahydrofuran / 3.33 h / -40 - 20 °C

3.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; ammonium chloride; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; mineral oil;