4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

Base Information

Chemical Name:4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine
CAS No.:1445891-02-0
Molecular Formula:C₁₉H₁₄ClFN₄
Molecular Weight:352.798
Hs Code.:

Synonyms:4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

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Chemical Property of 4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

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Technology Process of 4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

There total 6 articles about 4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1445891-01-9
4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrole-3-carbaldehyde

: 631-61-8,92206-38-7
ammonium acetate

: 1445891-02-0
4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

Guidance literature:: With glyoxal trimer dihydrate; acetic acid; In methanol; at 20 - 45 ℃; for 32h;

Reference yield:

: 1188163-01-0
ethyl 4-(2-chlorophenyl)-1H-pyrrole-3-carboxylate

: 1445891-02-0
4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

Guidance literature:: Multi-step reaction with 4 steps

1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

3: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

4: glyoxal trimer dihydrate; acetic acid / methanol / 32 h / 20 - 45 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; glyoxal trimer dihydrate; potassium carbonate; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane;

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 1445891-02-0
4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride; ammonium chloride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

1.2: 1 h / 20 °C

2.1: sodium t-butanolate / tetrahydrofuran / 3.33 h / -40 - 20 °C

3.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

4.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

5.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

6.1: glyoxal trimer dihydrate; acetic acid / methanol / 32 h / 20 - 45 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; glyoxal trimer dihydrate; sodium hydride; potassium carbonate; ammonium chloride; acetic acid; pyridinium chlorochromate; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; mineral oil;