4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

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Chemical Name:4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine
CAS No.:1445891-03-1
Molecular Formula:C₂₅H₂₈ClFN₄OSi
Molecular Weight:483.06
Hs Code.:

Synonyms:4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

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Chemical Property of 4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

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Technology Process of 4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

There total 7 articles about 4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1445891-02-0
4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1445891-03-1
4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

Guidance literature:: 4-[3-(2-chlorophenyl)-4-(1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1188163-01-0
ethyl 4-(2-chlorophenyl)-1H-pyrrole-3-carboxylate

: 1445891-03-1
4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

4.1: glyoxal trimer dihydrate; acetic acid / methanol / 32 h / 20 - 45 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C

5.2: 1 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; glyoxal trimer dihydrate; potassium carbonate; caesium carbonate; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 24393-51-9
(E)-ethyl 2-chlorocinnamate

: 1445891-03-1
4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-1H-pyrrol-1-yl]-2-fluoro-5-methylpyridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / tetrahydrofuran / 3.33 h / -40 - 20 °C

2.1: trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate / 1,4-dioxane / 48 h / 20 - 105 °C / Sealed tube

3.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere

4.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

5.1: glyoxal trimer dihydrate; acetic acid / methanol / 32 h / 20 - 45 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C

6.2: 1 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; lithium aluminium tetrahydride; glyoxal trimer dihydrate; potassium carbonate; caesium carbonate; acetic acid; pyridinium chlorochromate; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;