α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide

Base Information

Chemical Name:α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide
CAS No.:1194751-67-1
Molecular Formula:C₂₄H₁₉ClF₂N₄O₄S
Molecular Weight:532.955
Hs Code.:

Synonyms:α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide

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Chemical Property of α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide

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Technology Process of α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide

There total 9 articles about α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1194752-29-8
α-(4-chlorobenzenesulfonylamino)-3,5-difluorobenzeneacetamide

: 256956-42-0
3-[4-(bromomethyl)phenyl]-5-methyl-1,2,4-oxadiazole

: 1194751-67-1
α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

: methyl α-azido-3,5-difluorobenzeneacetate

: 1194751-67-1
α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / 2585.81 Torr

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 18.08 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C / Inert atmosphere

5.1: triethylamine / acetonitrile / 50 h / 0 - 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With water; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 210530-70-4
methyl 2-(3,5-difluorophenyl)acetate

: 1194751-67-1
α-((4-chlorobenzenesulfonyl)(4-(4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)methyl)amino)-3,5-difluorobenzeneacetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 18 h / Inert atmosphere; Reflux

2.1: sodium azide / acetonitrile / 20.5 h / 20 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / 2585.81 Torr

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

5.2: 18.08 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C / Inert atmosphere

7.1: triethylamine / acetonitrile / 50 h / 0 - 20 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

With N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); water; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;