5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole

Base Information

Chemical Name:5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole
CAS No.:884844-22-8
Molecular Formula:C₂₇H₂₈O₈
Molecular Weight:480.515
Hs Code.:

Synonyms:5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole

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Chemical Property of 5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole

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Technology Process of 5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole

There total 3 articles about 5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2139-43-7
5-bromo-6-(1,3-dioxolan-2-yl)benzo[d][1,3]dioxolane

: 884844-22-8
5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: 75 percent / tetrahydrofuran; hexane / -78 - 0 °C

2.1: 71 percent / NaH; KI / tetrahydrofuran / 18 h / 20 °C

With n-butyllithium; sodium hydride; potassium iodide; In tetrahydrofuran; hexane;
DOI:10.1021/jo052599x

Reference yield:

: 15930-53-7
6-bromo-3,4-methylenedioxybenzaldehyde

: 884844-22-8
5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / p-TsOH / benzene / 26 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 75 percent / tetrahydrofuran; hexane / -78 - 0 °C

3.1: 71 percent / NaH; KI / tetrahydrofuran / 18 h / 20 °C

With n-butyllithium; sodium hydride; toluene-4-sulfonic acid; potassium iodide; In tetrahydrofuran; hexane; benzene;
DOI:10.1021/jo052599x

Reference yield:

: 42202-83-5
α-2-<(1,3-dioxolan-2-yl)-4,5-methylenedioxyphenyl>-3,4,5-trimethoxybenzyl alcohol

: 884844-22-8
5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole

Guidance literature:: α-2-<(1,3-dioxolan-2-yl)-4,5-methylenedioxyphenyl>-3,4,5-trimethoxybenzyl alcohol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

benzyl halide; In tetrahydrofuran; mineral oil; at 20 ℃; for 18h;
DOI:10.1002/chem.201101909