2139-43-7

Basic information

• Product Name: 5-BROMO-6-[1,3]DIOXOLAN-2-YL-BENZO[1,3]DIOXOLE
• Synonyms: RARECHEM AL BP 0271;5-BROMO-6-[1,3]DIOXOLAN-2-YL-BENZO[1,3]DIOXOLE;Nsc30073;5-bromo-6-(1,3-dioxolan-2-yl)-1,3-benzodioxole
• CAS NO: 2139-43-7
• Molecular Formula: C₁₀H₉BrO₄
• Molecular Weight: 273.08
• Mol File: 2139-43-7.mol
• Article Data: 27

Chemical Properties

• Melting Point: 68-69.5 °C
• Boiling Point: 322.5 °C at 760 mmHg
• Flash Point: 130.5 °C
• Appearance: /
• Density: 1.682g/cm³
• Vapor Pressure: 0.000523mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 5-BROMO-6-[1,3]DIOXOLAN-2-YL-BENZO[1,3]DIOXOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-6-[1,3]DIOXOLAN-2-YL-BENZO[1,3]DIOXOLE(2139-43-7)
• EPA Substance Registry System: 5-BROMO-6-[1,3]DIOXOLAN-2-YL-BENZO[1,3]DIOXOLE(2139-43-7)

Safety Data

• Hazardous Substances Data: 2139-43-7(Hazardous Substances Data)

Usage

General Description

5-BROMO-6-[1,3]DIOXOLAN-2-YL-BENZO[1,3]DIOXOLE is a chemical compound with a molecular formula C10H7BrO4. It is a brominated derivative of benzo[1,3]dioxole, containing a dioxolan ring. This chemical is used in organic synthesis and pharmaceutical research as a building block in the development of new molecules with potential medicinal uses. Its unique structure and properties make it a valuable tool in the study of biological processes and drug discovery.

InChI:InChI=1/C10H9BrO4/c11-7-4-9-8(14-5-15-9)3-6(7)10-12-1-2-13-10/h3-4,10H,1-2,5H2

Upstream product

• 994-30-9 triethylsilyl chloride 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 120-57-0 piperonal 
• 107-21-1 ethylene glycol 

Downstream Products

• 179936-98-2 (+/-)-5-(1,3-dioxolanyl)-[6-(1-hydroxy-3-phenylpropyl)]-1,3-benzodioxole 
• 1379669-24-5 5-[methoxy(3,4,5-trimethoxyphenyl)methyl]-6-[1,3]dioxolan-2-ylbenzo[1,3]dioxole 
• 1379669-25-6 5-[naphth-2-ylmethoxy(3,4,5-trimethoxyphenyl)methyl]-6-[1,3]dioxolan-2-ylbenzo[1,3]dioxole 
• 1379669-30-3 1,4-bis{([1-(3,4,5-trimethoxyphenyl)]-{1-[1-(1,3-dioxolanyl)-4,5-(methylene-1,3-dioxy)]phenyl}methyl)}benzene 
• 1379669-35-8 6-[(naphth-2-ylmethoxy)-(3,4,5-trimethoxyphenyl)methyl]-benzo[1,3]dioxole-5-carbaldehyde 
• 30044-78-1 pseudocoptisine chloride 
• 17803-12-2 justicidin C 

Relevant articles and documents

Palladium-catalyzed annulation of arynes by 2-halobenzaldehydes: Synthesis of fluoren-9-ones

(Chemical Equation Presented) Arynes, generated in situ from 2-(trimethylsilyl)aryl triflates and CsF, undergo annulation by o-haloarenecarboxaldehydes in the presence of a Pd catalyst, providing a useful new method for the synthesis of fluoren-9-ones in good yields.

The effect of carbonyl on the isomerization of a galanthan ring system and total synthesis of (±)-β-lycorane

Lycorine-type alkaloids are privileged structures in drug development due to their attractive biological activities. In this paper, the carbonyl on the C ring was proved to have played a critical role in stereoselectivity during the synthesis process, and the galanthan skeleton with acis-B/C ring is more thermodynamically stable in its presence. Furthermore, the total synthesis of (±)-β-lycorane was successfully completed by employing the Michael addition reaction to construct the galanthan skeleton with atrans-B/C ring. This system might be applied to other structural types with similar stereochemistry setting.

COMPOUNDS FOR THE INHIBITION OF UNREGULATED CELL GROWTH

The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly cancer stem cells. Particularly, the invention relates to compounds of Formula I to XXII for the treatment of cancer.