Technology Process of 6-[(naphth-2-ylmethoxy)-(3,4,5-trimethoxyphenyl)methyl]-benzo[1,3]dioxole-5-carbaldehyde
There total 4 articles about 6-[(naphth-2-ylmethoxy)-(3,4,5-trimethoxyphenyl)methyl]-benzo[1,3]dioxole-5-carbaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Amberlite 120 IR.(R). / tetrahydrofuran / 24 h / 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
2.2: 18 h / 20 °C
3.1: hydrogenchloride / methanol; water / 60 h / 20 °C
With
hydrogenchloride; sodium hydride;
In
tetrahydrofuran; methanol; water; mineral oil;
1.1: Friedel Crafts-type reaction / 3.1: Friedel Crafts-type reaction;
DOI:10.1002/chem.201101909
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
2.2: 18 h / 20 °C
3.1: hydrogenchloride / methanol; water / 60 h / 20 °C
With
hydrogenchloride; n-butyllithium; sodium hydride;
In
tetrahydrofuran; methanol; hexane; water; mineral oil;
3.1: Friedel Crafts-type reaction;
DOI:10.1002/chem.201101909
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / benzene / 26 h / Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C
3.2: 18 h / 20 °C
4.1: hydrogenchloride / methanol; water / 60 h / 20 °C
With
hydrogenchloride; n-butyllithium; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; hexane; water; mineral oil; benzene;
4.1: Friedel Crafts-type reaction;
DOI:10.1002/chem.201101909