6-bromo-2-{1-[4-(methylsulfonyl)phenyl]pyrrolidin-2-yl}thieno[3,2-d]pyrimidin-4(3H)-one

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Chemical Name:6-bromo-2-{1-[4-(methylsulfonyl)phenyl]pyrrolidin-2-yl}thieno[3,2-d]pyrimidin-4(3H)-one
CAS No.:1330783-56-6
Molecular Formula:C₁₇H₁₆BrN₃O₃S₂
Molecular Weight:454.368
Hs Code.:

Synonyms:6-bromo-2-{1-[4-(methylsulfonyl)phenyl]pyrrolidin-2-yl}thieno[3,2-d]pyrimidin-4(3H)-one

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Chemical Property of 6-bromo-2-{1-[4-(methylsulfonyl)phenyl]pyrrolidin-2-yl}thieno[3,2-d]pyrimidin-4(3H)-one

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Technology Process of 6-bromo-2-{1-[4-(methylsulfonyl)phenyl]pyrrolidin-2-yl}thieno[3,2-d]pyrimidin-4(3H)-one

There total 6 articles about 6-bromo-2-{1-[4-(methylsulfonyl)phenyl]pyrrolidin-2-yl}thieno[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1330783-58-8
N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide

: 1330783-56-6
6-bromo-2-{1-[4-(methylsulfonyl)phenyl]pyrrolidin-2-yl}thieno[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide; With water; sodium hydroxide; In ethanol; at 70 ℃; for 10h;

With hydrogenchloride; In ethanol; water; at 20 ℃; Cooling with ice;

Reference yield:

: 107818-55-3
3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester

: 1330783-56-6
6-bromo-2-{1-[4-(methylsulfonyl)phenyl]pyrrolidin-2-yl}thieno[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide; water; methanol / 70 °C

1.2: 0.08 h / 20 °C

1.3: 120 h / 20 °C

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.2: 19 h / 60 °C

3.1: sodium hydroxide; water / ethanol / 10 h / 70 °C

3.2: 20 °C / Cooling with ice

With water; triethylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1330783-56-6
6-bromo-2-{1-[4-(methylsulfonyl)phenyl]pyrrolidin-2-yl}thieno[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / acetonitrile / 0 - 20 °C / Cooling with ice

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: potassium carbonate; methanol / water / 2 h / 20 °C

4.1: sodium hydroxide / N,N-dimethyl-formamide; water; methanol / 70 °C

4.2: 0.08 h / 20 °C

4.3: 120 h / 20 °C

5.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 0 - 20 °C

5.2: 19 h / 60 °C

6.1: sodium hydroxide; water / ethanol / 10 h / 70 °C

6.2: 20 °C / Cooling with ice

With pyridine; methanol; n-butyllithium; water; potassium carbonate; triethylamine; diisopropylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; ethanol; hexane; water; N,N-dimethyl-formamide; acetonitrile;