N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide

Base Information

Chemical Name:N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide
CAS No.:1330783-58-8
Molecular Formula:C₁₇H₁₈BrN₃O₄S₂
Molecular Weight:472.384
Hs Code.:

Synonyms:N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide

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Chemical Property of N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide

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Technology Process of N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide

There total 5 articles about N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 494833-79-3
3-amino-5-bromothiophene-2-carboxyamide

: 1330783-57-7
1-[4-(methylsulfonyl)phenyl]proline

: 1330783-58-8
N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide

Guidance literature:: 1-[4-(methylsulfonyl)phenyl]proline; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

3-amino-5-bromothiophene-2-carboxyamide; In tetrahydrofuran; at 60 ℃; for 19h;

Reference yield:

: 107818-55-3
3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester

: 1330783-58-8
N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide; water; methanol / 70 °C

1.2: 0.08 h / 20 °C

1.3: 120 h / 20 °C

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 0 - 20 °C

2.2: 19 h / 60 °C

With triethylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 22288-78-4
Methyl 3-aminothiophene-2-carboxylate

: 1330783-58-8
N-(5-bromo-2-carbamoylthiophen-3-yl)-1-[4-(methylsulfonyl)phenyl]prolinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / acetonitrile / 0 - 20 °C / Cooling with ice

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 1 h / -78 - 20 °C

3.1: potassium carbonate; methanol / water / 2 h / 20 °C

4.1: sodium hydroxide / N,N-dimethyl-formamide; water; methanol / 70 °C

4.2: 0.08 h / 20 °C

4.3: 120 h / 20 °C

5.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 0 - 20 °C

5.2: 19 h / 60 °C

With pyridine; methanol; n-butyllithium; potassium carbonate; triethylamine; diisopropylamine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; acetonitrile;