methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate

Base Information

Chemical Name:methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate
CAS No.:1190409-89-2
Molecular Formula:C₂₆H₃₃NO₆SSi
Molecular Weight:515.703
Hs Code.:

Synonyms:methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate

Suppliers and Price of methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate

There total 10 articles about methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 1190409-96-1
(2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetic acid

: 1190409-89-2
methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate

Guidance literature:: In diethyl ether; ethyl acetate; at 20 ℃;
DOI:10.1021/ja9063475

Reference yield:

: 960004-39-1
methyl (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-4-(phenylseleno)butanoate

: 1190409-89-2
methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / -1 - 1 °C / Inert atmosphere

2: dihydrogen peroxide / tetrahydrofuran; water / 16.5 h / 20 °C

3: (acetylacetonato)dicarbonylrhodium (l) / toluene / 13 h / 120 °C / 25858.1 Torr / Autoclave

4: methanol; sodium tetrahydroborate / 2 - 5 °C / Inert atmosphere

5: chromium(VI) oxide; periodic acid / water; acetonitrile / -1 - 6 °C

6: diethyl ether; ethyl acetate / Inert atmosphere

With chromium(VI) oxide; methanol; (acetylacetonato)dicarbonylrhodium (l); sodium tetrahydroborate; dihydrogen peroxide; periodic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; dichloromethane; water; ethyl acetate; toluene; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1021/jo101790z

Reference yield:

: 1190409-87-0
methyl (2S)-2-[[(4-methylphenyl)sulfonyl]-(2-butyn-1-yl)-amino]-4-(phenylseleno)butanoate

: 1190409-89-2
methyl (2S,3S,4E)-1-[(4-methylphenyl)sulfonyl]-2-methoxycarbonyl-4-[1-(phenyldimethylsilyl)ethylidene]-3-pyrrolidineacetate

Guidance literature:: Multi-step reaction with 5 steps

1: dihydrogen peroxide / tetrahydrofuran; water / 16.5 h / 20 °C

2: (acetylacetonato)dicarbonylrhodium (l) / toluene / 13 h / 120 °C / 25858.1 Torr / Autoclave

3: methanol; sodium tetrahydroborate / 2 - 5 °C / Inert atmosphere

4: chromium(VI) oxide; periodic acid / water; acetonitrile / -1 - 6 °C

5: diethyl ether; ethyl acetate / Inert atmosphere

With chromium(VI) oxide; methanol; (acetylacetonato)dicarbonylrhodium (l); sodium tetrahydroborate; dihydrogen peroxide; periodic acid; In tetrahydrofuran; diethyl ether; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jo101790z