3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy] phenyl}-1H-indole-6-carboxylic acid

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Chemical Name:3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy] phenyl}-1H-indole-6-carboxylic acid
CAS No.:1208130-13-5
Molecular Formula:C₃₀H₄₀N₄O₆S
Molecular Weight:584.737
Hs Code.:

Synonyms:3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy] phenyl}-1H-indole-6-carboxylic acid

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Chemical Property of 3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy] phenyl}-1H-indole-6-carboxylic acid

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Technology Process of 3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy] phenyl}-1H-indole-6-carboxylic acid

There total 8 articles about 3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy] phenyl}-1H-indole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1208130-12-4
methyl 3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy]phenyl}-1H-indole-6-carboxylate

: 1208130-13-5
3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy] phenyl}-1H-indole-6-carboxylic acid

Guidance literature:: methyl 3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy]phenyl}-1H-indole-6-carboxylate; With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; pH=5;

Reference yield:

: 1384353-58-5
C₃₄H₄₈N₄O₆S

: 1208130-13-5
3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy] phenyl}-1H-indole-6-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2012.03.097

Reference yield:

: 879498-90-5
1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester

: 1208130-13-5
3-cyclohexyl-1-methyl-2-{2-[2-({5-[methyl(sulfamoyl)amino]pentyl}amino)-2-oxoethoxy] phenyl}-1H-indole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydride / tetrahydrofuran / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 12 h / 100 °C

3: potassium carbonate / acetonitrile / 20 °C

4: water; lithium hydroxide / tetrahydrofuran; methanol

5: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran

6: caesium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C

7: sulfonamide / 1,4-dioxane / 0.75 h / 100 °C

8: trifluoroacetic acid / dichloromethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfonamide; water; sodium hydride; potassium carbonate; caesium carbonate; thiophenol; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki-Miyaura reaction;
DOI:10.1016/j.bmcl.2012.03.097