tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate

Base Information

• Chemical Name: tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate
• CAS No.: 1208130-14-6
• Molecular Formula: C₂₀H₂₆BrNO₂
• Molecular Weight: 392.336
• Mol file: 1208130-14-6.mol

Synonyms:tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate

Chemical Property of tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate

There total 1 articles about tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester (879498-90-5) + methyl iodide (74-88-4) → tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate (1208130-14-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate (1208130-14-6) + 2-hydroxyphenyl boronic acid (89466-08-0) → tert-butyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1-methyl-1H-indole-6-carboxylate (1208130-15-7)

Guidance literature:

With potassium carbonate; trans-bis(triphenylphosphine)palladium dichloride; In 1,2-dimethoxyethane; at 100 ℃; for 12h; Inert atmosphere;

Reference yield:

5-fluoro-2-hydroxyphenyl-boronic acid (259209-20-6) + tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate (1208130-14-6) → C26H30FNO3 (1384353-16-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 12h;

DOI:10.1016/j.bmcl.2012.03.097

upstream raw materials:

1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester

methyl iodide

Downstream raw materials:

tert-butyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1-methyl-1H-indole-6-carboxylate

C₂₆H₃₀FNO₃

C₂₇H₃₃NO₄

tert-butyl 3-cyclohexyl-2-[2-(2-methoxy-2-oxoethoxy)phenyl]-1-methyl-1H-indole-6-carboxylate