(1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol

Base Information

Chemical Name:(1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol
CAS No.:286853-92-7
Molecular Formula:C₃₇H₆₆O₅Si
Molecular Weight:619.014
Hs Code.:

Synonyms:(1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol

Suppliers and Price of (1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol

There total 1 articles about (1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 286854-02-2
(1R,2'R,2''R,5'R,5''R)-1-[5'-(5''-(tert-butyldimethylsilyloxy)methyltetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]-1-(tert-butyldimethylsilyloxy)-15-benzyloxypentadecan-1-one

: 286853-92-7
(1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol

Guidance literature:: With camphor-10-sulfonic acid; In methanol; dichloromethane; at -10 - 0 ℃;
DOI:10.1016/S0040-4039(99)01225-3

Reference yield: 90.0%

: 286853-92-7
(1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol

: 286853-93-8
(1'''R,2'R,2''R,5'R,5''R)-[5-(5'-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]carbaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 - 0 ℃;
DOI:10.1002/(SICI)1099-0690(200005)2000:10<1889::AID-EJOC1889>3.0.CO;2-R

Reference yield:

: 286853-92-7
(1'''R,2'R,2''R,5'R,5''R)-[5'-(5''-(1'''-tert-butyldimethylsilyloxy-15'''-benzyloxypentadec-1'''-yl)tetrahydrofuran-2''-yl)tetrahydrofuran-2'-yl]methanol

: 120298-30-8
squamocin

Guidance literature:: Multi-step reaction with 11 steps

1.1: 90 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -60 - 0 °C

2.1: Mg; BrCH₂CH₂Br / diethyl ether / 1 h / 35 °C

2.2: diethyl ether

3.1: 2,6-lutidine / CH₂Cl₂ / 2 h / -20 °C

4.1: 10percent Pd/C / propan-2-ol / 20 °C

5.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -50 - 0 °C

6.1: NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 20 °C

7.1: LDA; LiCl / tetrahydrofuran / 0.5 h / 20 °C

7.2: tetrahydrofuran / 20 °C

8.1: pivaloyl chloride; Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

9.1: LDA / tetrahydrofuran / 0 °C

9.2: tetrahydrofuran / 2 h / 0 - 20 °C

10.1: monoperoxyphthalic acid / tetrahydrofuran; methanol / 0.5 h / 20 °C

11.1: 82 percent / HF (5percent in CH₃CN) / tetrahydrofuran / 6 h / 20 °C

With 2,6-dimethylpyridine; sodium chlorite; sodium dihydrogenphosphate; monoperoxyphthalic acid; 2-methyl-but-2-ene; oxalyl dichloride; pivaloyl chloride; magnesium; dimethyl sulfoxide; ethylene dibromide; triethylamine; lithium chloride; lithium diisopropyl amide; 10percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; isopropyl alcohol; tert-butyl alcohol; 1.1: Oxidation / 2.1: Metallation / 2.2: Grignard reaction / 3.1: silylation / 4.1: Hydrogenolysis / 5.1: Oxidation / 6.1: Oxidation / 7.1: Metallation / 7.2: Substitution / 8.1: Cyclization / 9.1: Metallation / 9.2: Substitution / 10.1: Oxidation / 11.1: desilylation;
DOI:10.1002/(SICI)1099-0690(200005)2000:10<1889::AID-EJOC1889>3.0.CO;2-R