128742-77-8

Basic information

• Product Name: [N-(p-toluenesulfonyl)indol-3-yl]acetic acid
• Synonyms: [N-(p-toluenesulfonyl)indol-3-yl]acetic acid
• CAS NO: 128742-77-8
• Molecular Weight: 329.376
• Mol File: 128742-77-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: [N-(p-toluenesulfonyl)indol-3-yl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [N-(p-toluenesulfonyl)indol-3-yl]acetic acid(128742-77-8)
• EPA Substance Registry System: [N-(p-toluenesulfonyl)indol-3-yl]acetic acid(128742-77-8)

Safety Data

• Hazardous Substances Data: 128742-77-8(Hazardous Substances Data)

Upstream product

• 1912-33-0 Indole-3-acetic acid methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 1031685-23-0 2-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]methyl acetate 
• 58550-81-5 3-(bromomethyl)-1-[(4-methylphenyl)sulfonyl]-1H-indole 
• 201230-82-2 carbon monoxide 
• 87-51-4 indole-3-acetic acid 

Downstream Products

• 153413-51-5 tert-butyl [N-(p-toluenesulfonyl)indol-3-yl]acetate 
• 915706-91-1 2-(1-tosyl-1H-indol-3-yl)acetyl chloride 
• 1391630-42-4 2-[1-(4-methylphenylsulfonyl)-1H-indol-3-yl]N-(benzothiazol-2-yl)acetamide 
• 1228320-13-5 (1-p-toluenesulfonyl-1H-indol-3-yl)methyl acetate 
• 1626423-93-5 (E)-crotyl 2-(N-tosyl-3-indole)acetate 
• 934586-52-4 methyl 3-(3-(2-(benzyloxy)ethyl)-2-oxo-1-(2-(1-tosyl-1H-indol-3-yl)acetyl)-piperidin-3-yl)-2-diazo-3-oxopropanoate 

Relevant articles and documents

2-Hydroxyindoline-3-triethylammonium Bromide: A Reagent for Formal C3-Electrophilic Reactions of Indoles

A novel indole-2,3-epoxide equivalent, 2-hydroxyindoline-3-triethylammonium bromide, was found to be a convenient reagent for formal C3-electrophilic reactions of indoles with various nucleophiles. By taking advantage of the nucleophilic character of the

Enantioselective Syntheses of Strychnos and Chelidonium Alkaloids through Regio- and Stereocontrolled Cooperative Catalysis

We describe enantioselective syntheses of strychnos and chelidonium alkaloids. In the first case, indole acetic acid esters were established as excellent partner nucleophiles for enantioselective cooperative isothiourea/Pd catalyzed α-alkylation. This provides products containing indole-bearing stereocenters in high yield and with excellent levels of enantioinduction in a manner that is notably independent of the N-substituent. This led to concise syntheses of (?)-akuammicine and (?)-strychnine. In the second case, the poor performance of ortho-substituted cinnamyl electrophiles in the enantioselective cooperative isothiourea/Ir catalyzed α-alkylation was overcome by appropriate substituent choice, leading to enantioselective syntheses of (+)-chelidonine, (+)-norchelidonine, and (+)-chelamine.

Synthesis and biological evaluation of benzothiazole incorporated 1-phenylsulfonylindole-3-acetamide derivatives

Indole-3-acetic acid was esterified to give methyl ester (2), which was treated with substituted aromatic sulphonyl chloride in alkaline media to give 2-[1-(phenyl sufonyl-1H-indole-3-yl]methyl acetate (3). Further the compound 3 was converted to acid (4). Finally compound 4 was coupled with 6-substituted benzothiazole-2-amines by means of EDC to give acetamide derivatives (5a-i). The structures of the newly synthesized compounds have been established by analytical and spectral methods. These compounds have also been screened for analgesic activity.