ethyl (2E/Z)-2-((2,6-dichloro-5-fluoro-4-ethylpyridin-3-yl)carbonyl)-3-ethoxy-2-propenoate

Base Information

Chemical Name:ethyl (2E/Z)-2-((2,6-dichloro-5-fluoro-4-ethylpyridin-3-yl)carbonyl)-3-ethoxy-2-propenoate
CAS No.:132195-53-0
Molecular Formula:C₁₅H₁₆Cl₂FNO₄
Molecular Weight:364.201
Hs Code.:

Synonyms:ethyl (2E/Z)-2-((2,6-dichloro-5-fluoro-4-ethylpyridin-3-yl)carbonyl)-3-ethoxy-2-propenoate

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Chemical Property of ethyl (2E/Z)-2-((2,6-dichloro-5-fluoro-4-ethylpyridin-3-yl)carbonyl)-3-ethoxy-2-propenoate

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Technology Process of ethyl (2E/Z)-2-((2,6-dichloro-5-fluoro-4-ethylpyridin-3-yl)carbonyl)-3-ethoxy-2-propenoate

There total 1 articles about ethyl (2E/Z)-2-((2,6-dichloro-5-fluoro-4-ethylpyridin-3-yl)carbonyl)-3-ethoxy-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 132195-53-0
ethyl (2E/Z)-2-((2,6-dichloro-5-fluoro-4-ethylpyridin-3-yl)carbonyl)-3-ethoxy-2-propenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) ether, THF, -30 deg C, 2 h, 2.) ether, THF, from -60 to 0 deg C, 2 h

2: PCl₅ / 0.13 h / 100 °C

3: 2.) p-TsOH*H₂O / 1.) ether, RT, 2 h, 2.) H₂O, reflux, 2.5 h

4: Ac₂O / 15 h / 130 °C

With phosphorus pentachloride; acetic anhydride; toluene-4-sulfonic acid; lithium diisopropyl amide;
DOI:10.1021/jm00081a013

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 132195-45-0
2-(ethoxymethylene)-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxopropionic acid ethyl ester

: 132195-53-0
ethyl (2E/Z)-2-((2,6-dichloro-5-fluoro-4-ethylpyridin-3-yl)carbonyl)-3-ethoxy-2-propenoate

: 635309-59-0
ethyl 7-chloro-1-(2,4-dimethoxybenzyl)-6-fluoro-5-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

: 635309-58-9
ethyl 7-chloro-1-(2,4-dimethoxybenzyl)-6-fluoro-5-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

Guidance literature:: 2,4-Dimethoxybenzylamine; 2-(ethoxymethylene)-3-(2,6-dichloro-3-fluoro-4-methyl-5-pyridinyl)-3-oxopropionic acid ethyl ester; ethyl (2E/Z)-2-((2,6-dichloro-5-fluoro-4-ethylpyridin-3-yl)carbonyl)-3-ethoxy-2-propenoate; In dichloromethane; at 0 - 20 ℃; for 1.5h;

With potassium carbonate; In acetonitrile; for 216h; Heating / reflux;