Technology Process of [1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl4-methylbenzenesulfonate
There total 16 articles about [1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl4-methylbenzenesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C
2.1: trifluoroacetic anhydride; tetramethylammonium nitrate / dichloromethane / 20.5 h / -5 - 20 °C
3.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Inert atmosphere; Reflux
4.1: hydrogenchloride; water / acetone / 2 h / Reflux
5.1: toluene / 15 h / 85 °C
5.2: 2 h
5.3: 1 h / Reflux
6.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 5 h / Reflux
7.1: trichlorophosphate / chlorobenzene / 100 °C
8.1: 130 °C / Sealed tube; Inert atmosphere
9.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
10.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
10.2: 0 - 20 °C
With
hydrogenchloride; dmap; lithium aluminium tetrahydride; lithium hydroxide monohydrate; water; tetramethylammonium nitrate; sodium hydride; triethylamine; trifluoroacetic anhydride; trichlorophosphate;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; chlorobenzene; acetone; toluene;
- Guidance literature:
-
[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]methanol;
With
sodium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
p-toluenesulfonyl chloride;
In
tetrahydrofuran;
at 0 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium hydroxide / water; acetone / 0 °C
2.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 20 °C
3.1: 120 - 130 °C
4.1: Dowtherm A / 250 °C
5.1: sodium hydroxide; water / ethanol / Reflux
6.1: Dowtherm A / 250 °C
7.1: trichlorophosphate / chlorobenzene / 100 °C
8.1: 130 °C / Sealed tube; Inert atmosphere
9.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
10.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
10.2: 0 - 20 °C
With
lithium aluminium tetrahydride; Dowtherm A; water; hydrogen; sodium hydride; sodium hydroxide; trichlorophosphate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; chlorobenzene; acetone;
