2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

Base Information

Chemical Name:2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester
CAS No.:127446-46-2
Molecular Formula:C₂₄H₃₂N₂O₄
Molecular Weight:412.529
Hs Code.:

Synonyms:2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

Suppliers and Price of 2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

There total 4 articles about 2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 150942-98-6
t-butyl lithioacetate

: 127446-45-1
2,2-Dimethyl-N-<3-(4-methylbenzoyl)-2-pyridinyl>-propanamide

: 127446-46-2
2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo00302a049

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 127446-46-2
2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium diisopropyamide / diethyl ether; hexane / 0.33 h / -78 °C

2: 73 percent / tetrahydrofuran / -78 - 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/jo00302a049

Reference yield:

: 86847-59-8
2-(pivaloylamino)pyridine

: 127446-46-2
2-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-β-(4-methylphenyl)-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-butyllithium / 1) THF, 0 deg C, 3 h; 2) THF, room temp., 2 h

2: 73 percent / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; In tetrahydrofuran;
DOI:10.1021/jo00302a049