3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(4-methylpiperazin-1-yl)benzamide

Base Information

Chemical Name:3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(4-methylpiperazin-1-yl)benzamide
CAS No.:1403590-86-2
Molecular Formula:C₂₇H₃₉N₅O₂
Molecular Weight:465.639
Hs Code.:

Synonyms:3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(4-methylpiperazin-1-yl)benzamide

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Chemical Property of 3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(4-methylpiperazin-1-yl)benzamide

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Technology Process of 3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(4-methylpiperazin-1-yl)benzamide

There total 11 articles about 3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(4-methylpiperazin-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1403590-84-0
3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(piperazin-1-yl)benzamide

: 1403590-86-2
3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: formaldehyd; 3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(piperazin-1-yl)benzamide; In methanol; at 0 ℃; for 0.5h;

With methanol; sodium cyanoborohydride; at 20 ℃; for 4h;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403590-86-2
3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: acetic acid / methanol / 2 h / 20 °C

3.2: 16 h / 20 °C

4.1: caesium carbonate / acetonitrile / 12 h / 80 °C

5.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 8 h / 100 °C / Inert atmosphere

6.1: sodium hydroxide; water / methanol / 1 h / 60 °C

6.2: pH 4 - 6

7.1: dimethyl sulfoxide / 0.25 h / 20 °C

8.1: dichloromethane / 1 h / 20 °C

9.1: sodium hydrogencarbonate / water / pH 8

10.1: methanol / 0.5 h / 0 °C

10.2: 4 h / 20 °C

With water; iron; sodium hydrogencarbonate; sodium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1403590-86-2
3-(cyclopentyl(methyl)amino)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-5-(4-methylpiperazin-1-yl)benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

2.1: acetic acid / methanol / 2 h / 20 °C

2.2: 16 h / 20 °C

3.1: caesium carbonate / acetonitrile / 12 h / 80 °C

4.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 8 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide; water / methanol / 1 h / 60 °C

5.2: pH 4 - 6

6.1: dimethyl sulfoxide / 0.25 h / 20 °C

7.1: dichloromethane / 1 h / 20 °C

8.1: sodium hydrogencarbonate / water / pH 8

9.1: methanol / 0.5 h / 0 °C

9.2: 4 h / 20 °C

With water; iron; sodium hydrogencarbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; sodium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile;