(4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylMethyl)-2-oxazolidinone

Base Information

Chemical Name:(4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylMethyl)-2-oxazolidinone
CAS No.:474828-48-3
Molecular Formula:C₁₅H₁₉NO₃
Molecular Weight:261.321
Hs Code.:
Mol file:474828-48-3.mol

Synonyms:(R)-4-benzyl-3-((R)-2-methylbutanoyl) oxazolidin-2-one

Suppliers and Price of (4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylMethyl)-2-oxazolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylmethyl)-2-oxazolidinone
5g
$ 1100.00

TRC
(4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylmethyl)-2-oxazolidinone
500mg
$ 140.00

Medical Isotopes, Inc.
(4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylmethyl)-2-oxazolidinone
5 g
$ 2000.00

Medical Isotopes, Inc.
(4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylmethyl)-2-oxazolidinone
500 mg
$ 625.00

Total 1 raw suppliers

Chemical Property of (4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylMethyl)-2-oxazolidinone

Chemical Property:

Solubility.:DCM, Ethyl Acetate, Methanol

Purity/Quality:: (4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylmethyl)-2-oxazolidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (4R)- 3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylmethyl)-2-oxazolidinone is an intermediate in the synthesis of (R)-2-Methylbutyric Acid (M294365).

Technology Process of (4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylMethyl)-2-oxazolidinone

There total 3 articles about (4R)-3-[(2R)-2-Methyl-1-oxobutyl]-4-(phenylMethyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 111292-87-6,112459-79-7,143097-11-4
(R)-3-(1-butyryl)-4-benzyloxazolidine-2-one

: 74-88-4
methyl iodide

: 474828-48-3
(R)-4-benzyl-3-((R)-2-methylbutanoyl) oxazolidin-2-one

Guidance literature:: (R)-3-(1-butyryl)-4-benzyloxazolidine-2-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.cclet.2016.11.018

Reference yield: 80.0%

: 111292-87-6,112459-79-7,143097-11-4
(R)-3-(1-butyryl)-4-benzyloxazolidine-2-one

: 74-88-4
methyl iodide

: 474828-48-3
(R)-4-benzyl-3-((R)-2-methylbutanoyl) oxazolidin-2-one

: (R)-4-benzyl-3-((S)-2-methylbutanoyl)oxazolidin-2-one

Guidance literature:: (R)-3-(1-butyryl)-4-benzyloxazolidine-2-one; With sodium bis(trimethylsilyl)amide; In tetrahydrofuran; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 5h; optical yield given as %de;
DOI:10.1021/jo202642a

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 474828-48-3
(R)-4-benzyl-3-((R)-2-methylbutanoyl) oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ol402820d