(2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

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Chemical Name:(2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid
CAS No.:1427549-65-2
Molecular Formula:C₃₃H₃₅N₅O₄
Molecular Weight:565.672
Hs Code.:

Synonyms:(2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

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Chemical Property of (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

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Technology Process of (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

There total 7 articles about (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1427549-63-0
ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

: 1427549-65-2
(2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Guidance literature:: With water; lithium hydroxide; In 1,4-dioxane; isopropyl alcohol; at 60 - 85 ℃; for 0.583333h;

Reference yield:

: 5653-09-8
2-cyclohexyl-1-phenylethan-1-one

: 1427549-65-2
(2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / 1,4-dioxane; diethyl ether / 1.17 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 - 100 °C / Inert atmosphere

2.2: 0.33 h / 20 °C / Inert atmosphere

3.1: water; potassium hydroxide / 1,4-dioxane / 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide / 1,4-dioxane; isopropyl alcohol / 0.58 h / 60 - 85 °C

With water; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; lithium hydroxide; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 931-51-1
cyclohexylmagnesiumchloride

: 1427549-65-2
(2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc(II) chloride / diethyl ether / 0.33 h / 0 °C / Inert atmosphere

1.2: 19.5 h / 20 °C

2.1: bromine / 1,4-dioxane; diethyl ether / 1.17 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 - 100 °C / Inert atmosphere

3.2: 0.33 h / 20 °C / Inert atmosphere

4.1: water; potassium hydroxide / 1,4-dioxane / 2 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

6.1: water; lithium hydroxide / 1,4-dioxane; isopropyl alcohol / 0.58 h / 60 - 85 °C

With water; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; zinc(II) chloride; lithium hydroxide; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; isopropyl alcohol;