ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

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Chemical Name:ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate
CAS No.:1427549-63-0
Molecular Formula:C₃₅H₃₉N₅O₄
Molecular Weight:593.726
Hs Code.:

Synonyms:ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

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Chemical Property of ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

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Technology Process of ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

There total 6 articles about ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 863578-93-2
ethyl (2E)-3-(4-{[(1-aminocyclobutyl)carbonyl]amino}phenyl)prop-2-enoate hydrochloride

: 1427550-00-2
3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-carboxylic acid

: 1427549-63-0
ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 5653-09-8
2-cyclohexyl-1-phenylethan-1-one

: 1427549-63-0
ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / 1,4-dioxane; diethyl ether / 1.17 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 - 100 °C / Inert atmosphere

2.2: 0.33 h / 20 °C / Inert atmosphere

3.1: water; potassium hydroxide / 1,4-dioxane / 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With water; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 931-51-1
cyclohexylmagnesiumchloride

: 1427549-63-0
ethyl (2E)-3-(4-{[(1-{[(3-cyclohexyl-1-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazole-7-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc(II) chloride / diethyl ether / 0.33 h / 0 °C / Inert atmosphere

1.2: 19.5 h / 20 °C

2.1: bromine / 1,4-dioxane; diethyl ether / 1.17 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 19 h / 20 - 100 °C / Inert atmosphere

3.2: 0.33 h / 20 °C / Inert atmosphere

4.1: water; potassium hydroxide / 1,4-dioxane / 2 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With water; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; zinc(II) chloride; In 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide;