4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester

Base Information

• Chemical Name: 4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester
• CAS No.: 915380-02-8
• Molecular Formula: C₄₉H₅₀N₂O₃S₂
• Molecular Weight: 779.08
• Mol file: 915380-02-8.mol

Synonyms:4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester

Chemical Property of 4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester

There total 4 articles about 4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

Methyl 4-bromobutyrate (4897-84-1) + N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide (152863-83-7) → 4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester (915380-02-8)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile;

DOI:10.1016/j.bmcl.2006.08.050

Reference yield:

triphenylmethyl alcohol (76-84-6) → 4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester (915380-02-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / trifluoroacetic acid

2: 64 percent / Et₃N / CH₂Cl₂

3: 40 percent / KI; K₂CO₃ / acetonitrile

With potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2006.08.050

Reference yield:

2-amino tritylthio ethane (1095-85-8) → 4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester (915380-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / Et₃N / CH₂Cl₂

2: 40 percent / KI; K₂CO₃ / acetonitrile

With potassium carbonate; triethylamine; potassium iodide; In dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2006.08.050

upstream raw materials:

Methyl 4-bromobutyrate

N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide

triphenylmethyl alcohol

2-amino tritylthio ethane

Downstream raw materials:

N-[2-(tritylthio)ethylaminocarbonylmethyl]-N-[2-(tritylthio)ethyl]-4-aminobutyric acid