methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate

Base Information

Chemical Name:methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate
CAS No.:1285514-87-5
Molecular Formula:C₂₂H₂₁N₃O₄
Molecular Weight:391.426
Hs Code.:

Synonyms:methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate

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Chemical Property of methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate

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Technology Process of methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate

There total 6 articles about methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285514-51-3
5-[(E/Z)-(hydroxylmino)methyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

: 79-22-1
methyl chloroformate

: 1285514-87-5
methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate

Guidance literature:: 5-[(E/Z)-(hydroxylmino)methyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide; With hydrogenchloride; zinc; In tetrahydrofuran; water; at 60 ℃; for 0.25h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; pH=10; Cooling;

methyl chloroformate; With sodium hydrogencarbonate; In tetrahydrofuran; water; for 1h; pH=9 - 10;

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1285514-87-5
methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h

2.1: hydroxylamine hydrochloride; pyridine / methanol / 0.25 h

3.1: hydrogenchloride; zinc / water; tetrahydrofuran / 0.25 h / 60 °C

3.2: pH 10 / Cooling

3.3: 1 h / pH 9 - 10

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; zinc; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1285514-87-5
methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h

2.1: water; lithium hydroxide / tetrahydrofuran; methanol

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h

4.1: hydroxylamine hydrochloride; pyridine / methanol / 0.25 h

5.1: hydrogenchloride; zinc / water; tetrahydrofuran / 0.25 h / 60 °C

5.2: pH 10 / Cooling

5.3: 1 h / pH 9 - 10

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; zinc; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;