N-butyl-4-methyl-benzamide

Base Information

• Chemical Name: N-butyl-4-methyl-benzamide
• CAS No.: 5456-97-3
• Molecular Formula: C12H17 N O
• Molecular Weight: 191.273
• Hs Code.: 2924299090
• Mol file: 5456-97-3.mol

Synonyms:p-Toluamide,N-butyl- (8CI); N-Butyl-4-methylbenzamide; N-Butyl-p-toluamide; NSC 21764

Chemical Property of N-butyl-4-methyl-benzamide

Chemical Property:

• Vapor Pressure: 0.000128mmHg at 25°C
• Boiling Point: 334.4°Cat760mmHg
• Flash Point: 199.3°C
• PSA: 29.10000
• Density: 0.977g/cm³
• LogP: 2.91580

Purity/Quality:

99% ^*data from raw suppliers

N-butyl-4-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-butyl-4-methyl-benzamide

There total 36 articles about N-butyl-4-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

para-xylene (106-42-3) + N-butylamine (109-73-9,85404-21-3) → N-butyl-4-methylbenzamide (5456-97-3)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; at 20 ℃; for 12h; chemoselective reaction; Schlenk technique; Green chemistry;

DOI:10.1039/d1nj03982b

Reference yield: 92.0%

p-Toluic acid (99-94-5) + N-butylamine (109-73-9,85404-21-3) → N-butyl-4-methylbenzamide (5456-97-3)

Guidance literature:

With dmap; triethylamine; trichlorophosphate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1039/c3ra42887g

Reference yield: 91.0%

4-Methylbenzyl alcohol (589-18-4) + N-butylamine (109-73-9,85404-21-3) → N-butyl-4-methylbenzamide (5456-97-3)

Guidance literature:

With 1-methyl-1H-imidazole; 4,4'-Dimethoxy-2,2'-bipyridin; 9-azabicyclo<3.3.1>nonane-N-oxyl; oxygen; copper(l) chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; under 760.051 Torr; Reagent/catalyst; Solvent; Molecular sieve;

DOI:10.1021/jacs.6b03931

upstream raw materials:

4-methylbenzoyl azide

N-butylamine

2,2,2-trichloro-1-(4-methylphenyl)ethanone

O-(4-nitrophenyl)-N-(4-tolyl)carbamate

Downstream raw materials:

C₁₂H₁₆N₂O₂

n-butyl 4-methylbenzoate

Refernces

• 1、 Ebrahimi, Edris,Khalafi-Nezhad, Ali,Khalili, Dariush,Rousta, Marzieh. "CuO-decorated magnetite-reduced graphene oxide: a robust and promising heterogeneous catalyst for the oxidative amidation of methylarenes in waterviabenzylic sp3C-H activation". . p. 20007 - 20020. Retrieved 2021/11/12.
• 2、 Sahoo, Ashish Kumar,Dahiya, Anjali,Das, Bubul,Behera, Ahalya,Patel, Bhisma K.. "Visible-Light-Mediated Difunctionalization of Alkynes: Synthesis of β-Substituted Vinylsulfones Using O- And S-Centered Nucleophiles". . p. 11968 - 11986. Retrieved 2021/08/24.